LIPEMIA--CARBOHYDRATE AND GLYCERIDE METABOLISM

脂血症--碳水化合物和甘油酯的代谢

• 批准号: 6219293
• 负责人: GERALD M. REAVEN
• 金额: $ 0.06万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219293
• 关键词: antiatherogenic agent; blood lipid; carbohydrate metabolism; clinical research; coronary disorder; human subject; hyperlipidemia; hypolipidemia; insulin sensitivity /resistance; lipid metabolism; noninsulin dependent diabetes mellitus; pathologic process

The overall goal of this protocol is to define the link between insulin resistance and coronary heart disease (CHD). Different diets may have a great influence on lipids and postprandial lipemia. These different postprandial responses may have a direct link in observing how lipids can effect the artery wall in the formation of atherosclerosis. This response may differ in the insulin sensitive and insulin resistant and type 2 diabetic patient. Therefore in a subset of patients lipids changes will be observed in combinations of diet interventions after an 8 hour meal profile.

本方案的总体目标是确定胰岛素抵抗和冠心病（CHD）之间的联系。不同的饮食对血脂和餐后脂血症有很大的影响。这些不同的餐后反应可能与观察脂质如何影响动脉壁形成动脉粥样硬化有直接联系。这种反应在胰岛素敏感型和胰岛素抵抗型以及2型糖尿病患者中可能不同。因此，在一个患者亚组中，将在8小时进餐后结合饮食干预观察到脂质变化。