HETEROGENEITY AMONG HUMAN CD4+ T CELL CLONES

人类 CD4 T 细胞克隆的异质性

• 批准号: 6115007
• 负责人: DALE T UMETSU
• 金额: $ 4.03万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115007
• 关键词: allergens; alveolar macrophages; antigen presenting cell; cellular immunity; clinical research; clone cells; cytokine; helper T lymphocyte; human subject; hypersensitivity desensitization; immune tolerance /unresponsiveness; inflammation; interleukin 4; respiratory hypersensitivity; tissue /cell culture

The goal of our research protocols is to determine how the regulation of cytokine synthesis differs in allergic and non-allergic individuals. Toward this end, our objectives are to determine the cellular and molecular mechanisms that control IL-4 expression in CD4+ T cells. In some of these studies, we are focused on determining the role of antigen presenting cells and the role of genetic predisposition on cytokine synthesis in CD4+ T cells. The studies performed in the GCRC involve examination of alveolar macrophages from the lungs of allergic and non-allergic individuals, and determining how such antigen presenting cells influence cytokine production and how they induce tolerance in T cells. These studies of cytokine regulation in CD4+ T cells will lead to a better understanding of the critical immunologic response that underlie allergy and tolerance induction. Such an understanding will be key in the design of novel immunotherapies for diseases such as allergy and autoimmunity.

我们研究方案的目标是确定 细胞因子的合成在过敏和非过敏个体中是不同的。 为此，我们的目标是确定细胞和 控制IL-4在CD 4 + T细胞中表达的分子机制。在 在这些研究中，我们专注于确定 抗原提呈细胞和遗传易感性在 CD 4 + T细胞中的细胞因子合成。在GCRC中进行的研究 包括检查过敏性肺的肺泡巨噬细胞 和非过敏性个体，并确定这种抗原 呈递细胞影响细胞因子的产生以及它们如何诱导 T细胞的耐受性。这些关于CD 4 + T细胞中细胞因子调节的研究 细胞将导致更好地理解关键的免疫学 过敏和耐受诱导的基础反应。这样的 理解将是设计新型免疫疗法的关键， 过敏和自身免疫等疾病。