PSEUDOHYPOALDOSTERONISM--PATHOPHYSIOLOGY AND TREATMENT

假性醛固酮增多症--病理生理学和治疗

• 批准号: 6115153
• 负责人: BRUCE S KEENAN
• 金额: $ 3.42万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115153
• 关键词: ACE inhibitors; child (0-11); clinical research; developmental nutrition; dietary potassium; dietary sodium; electrolyte balance; endocrine disorder chemotherapy; human subject; human therapy evaluation; hyperkalemias; hypoaldosteronism; muscle function; nutrition related tag; orphan disease /drug; pathologic process; pediatrics

Unique opportunity to study 12yo boy with pseudohypoaldosteronism, to determine 1) his sodium and potassium replacement requirements, 2) the effect of variations in intake of these ions on muscle function and endurance, 3) the effect of an angiotensin converting enzyme inhibitor on electrolyte balance, and 4) the effect of oral K-exelate on the control of hyperkalemia. It is hoped this information will lead to improved care for this patient and better understanding of the treatment of this rare disorder.

独特的机会来研究12岁的男孩与假性醛固酮减少症， 确定1）他的钠和钾的替代需求，2） 这些离子摄入量的变化对肌肉功能的影响， 耐力，3）血管紧张素转换酶抑制剂对 电解质平衡，和4）口服K-exelate对控制 高钾血症 希望这些信息能够改善患者的护理 这种病人和更好地了解这种罕见的治疗 disorder.