ANDROGEN STIMULATED PUBERTAL GROWTH--ROLE OF GH AND IGF1

雄激素刺激青春期生长——GH 和 IGF1 的作用

• 批准号: 6115148
• 负责人: BRUCE S KEENAN
• 金额: $ 3.42万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115148
• 关键词: adolescence (12-20); blood chemistry; child (0-11); child physical development; clinical research; dihydrotestosterone; estradiol; hormone regulation /control mechanism; hormone therapy; human puberty; human subject; human therapy evaluation; hypogonadism; insulinlike growth factor; male; reproductive system disorder chemotherapy; somatotropin; testosterone

Analyzes the androgenic and estrogenic effects of testosterone (T) in stimula-ting growth and the production of growth hormone (GH) and IGF1 at puberty. Boys with delayed puberty will be treated either with T or dihydrotestosterone (DHT). Those effects seen with T treatment but not with DHT are attributable to estradiol, whereas the effects of DHT are considered purely androgenic. Para-meters to be followed include height velocity, bone age, spontaneous and stimulated plasma GH, and IGF1.

分析了睾酮(T)在青春期刺激生长、生长激素(GH)和胰岛素样生长因子(IGF1)产生的雄激素和雌激素效应。青春期延迟的男孩将接受T或双氢睾酮(DHT)治疗。这些效应可归因于雌二醇，而DHT的作用被认为纯粹是雄激素的作用。观察指标包括身高、骨龄、自发性和刺激性血浆GH和IGF1。