NEUROTRANSMITTER REGULATION OF GROWTH HORMONE SECRETION

生长激素分泌的神经递质调节

• 批准号: 6115142
• 负责人: BRUCE S KEENAN
• 金额: $ 3.42万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115142
• 关键词: 5 hydroxytryptophan; apomorphine; child (0-11); child physical development; clinical research; clonidine; dihydroxyphenylalanine; endocrine disorder diagnosis; hormone regulation /control mechanism; human subject; insulin; postnatal growth disorder; secretion; somatotropin

The hypothesis that some children with short stature have defects in their ability to regulate growth hormone secretion that is not detected by the standard provocative test will be tested by studying several categories of short children. Studies will include 24hr pump for growth hormone secretion, insulin/L-dopa, apomorphine, clonidine, and 5-hydroxytryptophan tests.

一些身材矮小的儿童在调节生长激素分泌的能力上存在缺陷，而标准激发试验无法检测到这种缺陷，这一假设将通过研究几类矮小的儿童来检验。 研究将包括用于生长激素分泌的 24 小时泵、胰岛素/左旋多巴、阿扑吗啡、可乐定和 5-羟色氨酸测试。