SUBSTITUTE RAS FOR HERPESVIRUS SAIMIRI STP ONCOGENE IN LYMPHOCYTE TRANSFORMATION
SUBSTITUTE RAS FOR HERPESVIRUS SAIMIRI STP ONCOGENE IN LYMPHOCYTE TRANSFORMATION
批准号:
6116560
负责人:
JIE GUO
金额:
$11.16万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-05-01 至 2000-04-30
中文摘要
STP-C488(C组疱疹病毒488株的STP
[C488])是唯一与之相关的病毒编码蛋白
细胞ras和激活ras信号转导通路
探讨ras信号转导在细胞免疫中的重要作用
STP依赖的生长转化,我们构建了重组
其中STP-C488癌基因被替换的人类免疫缺陷病毒C488菌株
细胞内正常ras(c-ras)或病毒致癌ras(v-ras)重组
人类免疫缺陷病毒STP/v-ras永生化恒河猴原代T淋巴细胞
白细胞素-2独立生长与野生型HHS C488一样有效
(WT HVS),而重组HVS STP/c-ras效率较低
而wt HVS使CD4-CD8+单阳性T淋巴细胞永生化,
HVS STP/c-ras-和HVS STP/v-ras永生化细胞主要是
CD4+CD8+双阳性T淋巴细胞及人类免疫缺陷综合征
STP/v-ras永生化T细胞高水平表达ras
并表现出黏附的巨噬细胞样形态特征
可能是由于AP-1转录的剧烈激活所致
因子活性:HVS STP/v-ras和HVS STP/c-ras各自诱导
两种常见的绒猴中的一种发生淋巴瘤,尽管发病时间是
对于v-ras病毒,这些结果更快地表明ras可以
替代人类免疫缺陷病毒C488的STP癌基因,使其永生化
初级淋巴样细胞的生长和活化形式的ras
这样做比ras的正常细胞形式更有效。
出版物:郭,威廉姆斯,K,杜博伊斯,SM,亚历山大,L,韦兹,R.
和Jung,Ju用ras取代疱疹病毒saimiri stp
淋巴细胞转化中的癌基因J Virol 1998;72:3698-3704
英文摘要
STP-C488 (STP of herpesvirus saimiri [HVS] group C strain 488
[C488]) is the only virus-encoded protein found to associate with
cellular ras and activate ras signal transduction pathways To
investigate an important role for ras signal transduction in
STP-dependent growth transformation, we constructed recombinant
strains of HVS C488 in which the STP-C488 oncogene was replaced with
cellular normal ras (c-ras) or viral oncogenic ras (v-ras) Recombinant
HVS STP/v-ras immortalized primary common marmoset T lymphocytes to
inter-leukin-2-independent growth as efficiently as wild-type HVS C488
(wt HVS), while recombinant HVS STP/c-ras did so with low efficiency
Whereas wt HVS immortalized CD4- CD8+ single-positive T lymphocytes,
HVS STP/c-ras- and HVS STP/v-ras-immortalized cells were principally
CD4+ CD8+ double-positive T lymphocytes In addition, HVS
STP/v-ras-immortalized T cells showed a high level of ras expression
and exhibited an adherent macrophage-like morphol ogy These phenotypes
were likely caused by the drastic activation of AP-1 transcriptional
factor activity Finally, HVS STP/v-ras and HVS STP/c-ras each induced
lymphoma in one of two common marmosets, although onset of disease was
more rapid with the v-ras virus These results demonstrate that ras can
substitute for the STP oncogene of HVS C488 to allow immortalized
growth of primary lymphoid cells and that an activated form of ras
does so more efficiently than the normal cellular form of ras
PUBLICATIONS Guo, J, Williams, K, Duboise, SM, Alexander, L, Veazey, R
and Jung, JU Substitution of ras for the herpesvirus saimiri STP
oncogene in lymphocyte transformation J Virol 1998; 72:3698-3704
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会议论文
SUBSTITUTE RAS FOR HERPESVIRUS SAIMIRI STP ONCOGENE IN LYMPHOCYTE TRANSFORMATION
-
批准号:6591297
-
项目类别:
-
资助金额:$11.11万
-
财政年份:2002
-
负责人:JIE GUO
-
依托单位:
SUBSTITUTE RAS FOR HERPESVIRUS SAIMIRI STP ONCOGENE IN LYMPHOCYTE TRANSFORMATION
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批准号:6453743
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项目类别:
-
资助金额:$11.11万
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财政年份:2001
-
负责人:JIE GUO
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依托单位:
DEVELOPMENTAL RELATIONS OF SUBSTANCE USE AND RISKY SEX
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批准号:6159989
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项目类别:
-
资助金额:$6.15万
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财政年份:2000
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负责人:JIE GUO
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依托单位:
DOWNREG LCK MEDIATED SIGNAL TRANSDUC BY Y114 MUTATION OF HERPESVIRUS SAIMIRI TIP
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批准号:6277789
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项目类别:
-
资助金额:$7.85万
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财政年份:1998
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负责人:JIE GUO
-
依托单位:
海外基金