PATHOGENESIS OF DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE I DIABETES MELLITUS

I 型糖尿病患者糖尿病肾病的发病机制

• 批准号: 6117143
• 负责人: SHARON G ADLER
• 金额: $ 3.89万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117143
• 关键词: biopsy; clinical research; diabetic nephropathy; growth factor; human genetic material tag; human subject; insulin dependent diabetes mellitus; medical complication; messenger RNA; pathologic process; peptide structure; renal glomerulus; renal tubule

Performance of renal biopsies in living related transplant donors and in patients with type 1 DM (normoalbuminuria, microalbuminuria and overt nephropathy. Comparisons among the groups for glomerular and tubulinterstitial TGF-B1, PDGF, procollagen a2(IV), Type IV collagenase and control B-actin at the MRNA and peptide levels. To use tissue from kidney biopsies to identify factors which contribute to the development and/or worsening of diabetic kidney disease.

亲属活体移植供者肾活检的性能， 在1型糖尿病患者中（正常白蛋白尿、微量白蛋白尿和明显的 肾病各组间肾小球和 肾小管间质TGF-β 1、PDGF、前胶原α 2（IV）、IV型胶原酶 并在mRNA和肽水平上控制B-肌动蛋白。使用组织从 肾活检，以确定有助于发展的因素 和/或糖尿病肾病恶化。