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PATHOGENESIS OF DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE I DIABETES MELLITUS

PATHOGENESIS OF DIABETIC NEPHROPATHY IN PATIENTS WITH TYPE I DIABETES MELLITUS
I 型糖尿病患者糖尿病肾病的发病机制
批准号：
6219906
负责人：
SHARON G ADLER
金额：
$0.1万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6219906
关键词：
biopsy clinical research diabetic nephropathy growth factor human genetic material tag human subject insulin dependent diabetes mellitus medical complication messenger RNA pathologic process peptide structure renal glomerulus renal tubule

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英文摘要
Performance of renal biopsies in living related transplant donors and in patients with type 1 DM (normoalbuminuria, microalbuminuria and overt nephropathy. Comparisons among the groups for glomerular and tubulinterstitial TGF-B1, PDGF, procollagen a2(IV), Type IV collagenase and control B-actin at the MRNA and peptide levels. To use tissue from kidney biopsies to identify factors which contribute to the development and/or worsening of diabetic kidney disease.
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