EFFECT OF ALPHA MSH ON INFLAMMATION

ALPHA MSH 对炎症的影响

• 批准号: 6117554
• 负责人: Robert A Star
• 金额: $ 3.48万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6117554
• 关键词: clinical research; cytokine; dialysis; disease /disorder prevention /control; human subject; inflammation; melanocyte stimulating hormone

Some patients on long-time dialysis therapy suffer anorexia, wasting, hypertension, beta2 microglobulin accumulation, and frequent infections. Many of these complications are thought to be caused by activation of circulating inflamatory cells through contact with the dialyzer membrane. The activated cells produce substances called pro-inflammatory cytokines which are thought to increase breakdown of muscle tissue and cause systemic symptoms as listed above. This study will examine the action of alpha-Melanocyte Stimulating Hormone on cytokine production in dialysis patients. Laboratory evidence in cultured cells and whole animals indicate that alpha-MSH can inhibit production of pro-inflammatory cytokines in many forms of inflammation. We propose to determine if alpha-MSH can prevent the inflammatory state induced by dialysis and thereby, reduce short-term and long-term side effects.

一些长期接受透析治疗的患者会出现厌食、消瘦、高血压、β 2微球蛋白蓄积和频繁感染。这些并发症中的许多被认为是由于通过与透析器膜接触而激活循环炎症细胞引起的。激活的细胞产生称为促炎细胞因子的物质，其被认为增加肌肉组织的分解并引起如上所列的全身症状。本研究将检查α-黑素细胞刺激激素对透析患者细胞因子产生的作用。 培养细胞和整个动物的实验室证据表明，α-MSH可以抑制许多形式的炎症中促炎细胞因子的产生。 我们建议确定α-MSH是否可以预防透析引起的炎症状态，从而减少短期和长期的副作用。