Inhibition of renal injury

抑制肾损伤

• 批准号: 6421397
• 负责人: Robert A Star
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6421397
• 关键词: acute renal failure; chemoprevention; disease /disorder model; drug design /synthesis /production; interleukin 10; melanocyte stimulating hormone; renal ischemia /hypoxia; reperfusion

Acute renal failure has a high morbidity and mortality. We are working on the mechanism of action of two drugs(a-MSH and IL-10)that protect against renal injury in an animal model called ischemia-repercusion injury. We are also testing these agents in other forms of renal injury. Because this animal model does not reproduce many features of human acute renal failure, we are trying to find a better animal model. We have not suceeded yet.

急性肾衰竭的发病率和死亡率很高。我们正在研究两种药物（α-MSH和IL-10）的作用机制，这些药物在称为缺血-再灌注损伤的动物模型中保护肾损伤。我们还在其他形式的肾损伤中测试这些药物。由于该动物模型不能再现人类急性肾功能衰竭的许多特征，我们正在努力寻找更好的动物模型。我们还没有成功。