PRESENCE OF ENZYME PC4 IN TESTICULAR TUMOR

睾丸肿瘤中酶 PC4 的存在

• 批准号: 6219969
• 负责人: THEODORE FRIEDMAN
• 金额: $ 0.1万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6219969
• 关键词: clinical research; enzymes; hormone related neoplasm /cancer; human subject; neoplastic transformation; testis; testis neoplasms

Hormones are synthesized in larger inactive forms and then are activated by enzymatic digestion. A recently described enzyme, PC4, has been found only in the testis. Its role in the testis is unknown, as is the hormone that it acts upon. The present study is designed to test for the presence of PC4 in human testicular tumors and to see if it has a role in tumor formation. During the coming year additional testicular tumors will be collected by the GCRC.

激素以较大的非活性形式合成，然后通过酶消化激活。最近发现的一种酶PC4只存在于睾丸中。它在睾丸中的作用是未知的，它所作用的激素也是未知的。本研究旨在检测PC4在人类睾丸肿瘤中的存在，并观察它是否在肿瘤形成中起作用。在接下来的一年里，GCRC将收集更多的睾丸肿瘤。