PRESENCE OF ENZYME PC4 IN TESTICULAR TUMOR

睾丸肿瘤中酶 PC4 的存在

• 批准号: 6278401
• 负责人: THEODORE FRIEDMAN
• 金额: $ 3.92万
• 依托单位: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6278401
• 关键词: clinical research; enzymes; hormone related neoplasm /cancer; human subject; neoplastic transformation; testis; testis neoplasms

Hormones are synthesized in larger inactive forms and then are activated by enzymatic digestion. A recently described enzyme, PC4, has been found only in the testis. Its role in the testis is unknown, as is the hormone that it acts upon. The present study is designed to test for the presence of PC4 in human testicular tumors and to see if it has a role in tumor formation. During the coming year additional testicular tumors will be collected by the GCRC.

激素以较大的非活性形式合成，然后被激活 通过酶消化。 最近描述的一种酶，PC4， 只在睾丸中发现 它在睾丸中的作用尚不清楚， 它所作用的激素。 本研究旨在测试 PC4在人类睾丸肿瘤中的存在，并观察它是否具有 在肿瘤形成中的作用在未来的一年里，更多的睾丸 将由GCRC收集肿瘤。