CLINICAL TRIAL: HORMONE GEL APPLIED TO WOMEN WITH PITUITARY GLAND PROBLEMS

临床试验：激素凝胶适用于患有脑垂体问题的女性

• 批准号: 8173588
• 负责人: THEODORE FRIEDMAN
• 金额: $ 4.18万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173588
• 关键词: Blood; Blood Tests; Body Composition; Clinical Trials; Cognition; Computer Retrieval of Information on Scientific Projects Database; Estrogens; Fatigue; Functional disorder; Funding; Future; Gel; Gonadal Steroid Hormones; Grant; Hormones; Hydrocortisone; Institution; Libido; Measures; Medical center; Muscle function; Pituitary Gland; Play; Preparation; Production; Quality of life; Questionnaires; Research; Research Personnel; Resources; Role; Series; Serum; Sex Functioning; Source; Testing; Testosterone; Thyroid Gland; United States National Institutes of Health; Universities; Woman; absorption; dosage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Women who have pituitary gland dysfunction often have decreased production of a number of hormones, including thyroid hormonee, cortisol and sex hormones like estrogen and testosterone. As part of the treatment, these deficient hormones are normally replaced with exception of testosterone in women. However, testosterone may play an important role in women especially in terms of maintaining lean body mass and enhancing libido and general well being. This study, in general, looks to identify the effects of low testosterone in women with pituitary dysfunction as compared with normal women. At Charles R. Drew University, the subjects will undergo baseline blood tests for homone levels, tests for body composition and muscle function, as well as questionnaire tests evaluating fatigue, cognition, subjective sexual function and quality of life. At UCLA Medical Center, objective measures of sexual function will be assessed. Also at Charles R. Drew University, the absorption of a testosterone gel preparation given for seven days will be measured through a series of blood draws to determine testosterone serum concentrations. This will enable determination of appropriate replacement dosage of testosterone gel for a future study.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 患有脑下垂体功能障碍的女性通常会减少一些激素的分泌，包括甲状腺激素、皮质醇以及雌激素和睾酮等性激素。作为治疗的一部分，这些缺乏的荷尔蒙通常会被替代，但女性的睾丸素除外。然而，睾丸激素可能在女性身上扮演着重要的角色，特别是在保持苗条的身体质量、提高性欲和总体幸福感方面。总体而言，这项研究旨在确定与正常女性相比，低睾酮对垂体功能障碍女性的影响。在查尔斯·R·德鲁大学，受试者将接受荷尔蒙水平的基线血液测试，身体成分和肌肉功能测试，以及评估疲劳、认知、主观性功能和生活质量的问卷测试。在加州大学洛杉矶分校医学中心，将对性功能的客观测量进行评估。同样在查尔斯·R·德鲁大学，服用七天的睾酮凝胶制剂的吸收将通过一系列抽血来确定睾酮血清浓度来测量。这将为将来的研究确定合适的睾酮凝胶替代剂量。