CLINICAL TRIAL: HORMONE GEL APPLIED TO WOMEN WITH PITUITARY GLAND PROBLEMS

临床试验：激素凝胶适用于患有脑垂体问题的女性

• 批准号: 8359851
• 负责人: THEODORE FRIEDMAN
• 金额: $ 3.64万
• 依托单位: CHARLES R. DREW UNIVERSITY OF MED & SCI
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8359851
• 关键词: Blood; Blood Tests; Body Composition; Clinical Trials; Cognition; Estrogens; Fatigue; Functional disorder; Funding; Future; Gel; Gonadal Steroid Hormones; Grant; Hormones; Hydrocortisone; Libido; Measures; Medical center; Muscle function; National Center for Research Resources; Pituitary Gland; Play; Preparation; Principal Investigator; Production; Quality of life; Questionnaires; Research; Research Infrastructure; Resources; Role; Series; Serum; Sex Functioning; Source; Testing; Testosterone; Thyroid Gland; Translational Research; United States National Institutes of Health; Universities; Woman; absorption; cost; dosage

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Women who have pituitary gland dysfunction often have decreased production of a number of hormones, including thyroid hormonee, cortisol and sex hormones like estrogen and testosterone. As part of the treatment, these deficient hormones are normally replaced with exception of testosterone in women. However, testosterone may play an important role in women especially in terms of maintaining lean body mass and enhancing libido and general well being. This study, in general, looks to identify the effects of low testosterone in women with pituitary dysfunction as compared with normal women. At Charles R. Drew University, the subjects will undergo baseline blood tests for homone levels, tests for body composition and muscle function, as well as questionnaire tests evaluating fatigue, cognition, subjective sexual function and quality of life. At UCLA Medical Center, objective measures of sexual function will be assessed. Also at Charles R. Drew University, the absorption of a testosterone gel preparation given for seven days will be measured through a series of blood draws to determine testosterone serum concentrations. This will enable determination of appropriate replacement dosage of testosterone gel for a future study.

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