CLINICAL TRIAL: HORMONE GEL APPLIED TO WOMEN WITH PITUITARY GLAND PROBLEMS

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 患有脑下垂体功能障碍的女性通常会减少一些激素的产生，包括甲状腺激素，皮质醇和性激素，如雌激素和睾丸激素。作为治疗的一部分，这些缺乏的激素通常会被替换，但女性中的睾酮除外。然而，睾丸激素可能在女性中发挥重要作用，特别是在保持瘦体重和增强性欲和整体健康方面。这项研究，在一般情况下，寻找确定与正常妇女相比，垂体功能障碍的妇女低睾酮的影响。在查尔斯河德鲁大学，受试者将接受基线血液测试的激素水平，身体成分和肌肉功能的测试，以及问卷测试评估疲劳，认知，主观性功能和生活质量。在加州大学洛杉矶分校医学中心，将评估性功能的客观指标。在Charles R。德鲁大学，吸收的睾酮凝胶制剂给予七天将通过一系列的抽血测量，以确定睾酮血清浓度。这将有助于确定未来研究中睾酮凝胶的适当替代剂量。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Women who have pituitary gland dysfunction often have decreased production of a number of hormones, including thyroid hormonee, cortisol and sex hormones like estrogen and testosterone. As part of the treatment, these deficient hormones are normally replaced with exception of testosterone in women. However, testosterone may play an important role in women especially in terms of maintaining lean body mass and enhancing libido and general well being. This study, in general, looks to identify the effects of low testosterone in women with pituitary dysfunction as compared with normal women. At Charles R. Drew University, the subjects will undergo baseline blood tests for homone levels, tests for body composition and muscle function, as well as questionnaire tests evaluating fatigue, cognition, subjective sexual function and quality of life. At UCLA Medical Center, objective measures of sexual function will be assessed. Also at Charles R. Drew University, the absorption of a testosterone gel preparation given for seven days will be measured through a series of blood draws to determine testosterone serum concentrations. This will enable determination of appropriate replacement dosage of testosterone gel for a future study.