METABOLISM & FUNCTION OF FAT SOLUBLE VITAMINS

代谢

• 批准号: 6298142
• 负责人: HECTOR F DE LUCA
• 金额: $ 0.75万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6298142
• 关键词: biological products; biomaterials; biomedical resource; nuclear magnetic resonance spectroscopy; proteins

9-cis retinoic acid, which is an endogenous retinoic acid isomer, is capable of binding to both RARs and retinoid X receptors (RXRs). In order to study the ligand binding and other properties of this retinoic acid, we needed to synthesize [3H1]9-cis retinoic acid. Initially, we planned to develope a synthetic strategy for making cold 9-cis retinoic acid and then extend this strategy to the synthesis of "hot" 9-cis retinoic acid. We have completed the synthesis of the cold 9-cis retinoic acid and are currently working on the synthesis of radioactive 9-cis retinoic acid.

9-顺式视黄酸，其是内源性视黄酸异构体， 能够与RAR和类维生素A X受体（RXR）结合。 为了研究配体结合和其他性质， 为了合成[3 H]9-顺式维甲酸，我们需要合成[3 H]9-顺式维甲酸。 最初，我们计划开发一种合成策略， 9-顺式视黄酸，然后将此策略扩展到合成 “热”9-顺式视黄酸。 我们已经完成了 冷9-顺式视黄酸，目前正在合成 放射性9-顺式视黄酸。