课题基金 / 基金详情

ACTIVATION OF CARCINOGENS BY UROTHELIUM IN VITRO

ACTIVATION OF CARCINOGENS BY UROTHELIUM IN VITRO
尿路上皮在体外激活致癌物质
批准号:
6298196
负责人:
SANTHANAM SWAMINATHAN
金额:
$0.75万
依托单位国家:
美国
项目类别:
财政年份:
1999
资助国家:
美国
项目状态:
已结题
起止时间:
1999-03-01 至 2000-02-29

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中文摘要
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英文摘要
The major goal of this project is to: Determine the metabolic capabilities of the human uroepithelial cells, for activation of 4-aminobiphenyl and its N-hydroxy metabolites. Identify which of the proximate metabolites are converted to reactive electrophilic species. Identify the DNA-adducts that are generated by interaction of the ultimate electrophile with the DNA. Evaluate the biological effects of interaction of 4-aminobiphenyl derivatives with urothelial DNA - at the level of (A) mutation and (B) neoplastic transformation.
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ACTIVATION OF CARCINOGENS BY UROTHELIUM IN VITRO
  • 批准号:
    6309199
  • 项目类别:
  • 资助金额:
    $0.75万
  • 财政年份:
    2000
  • 负责人:
    SANTHANAM SWAMINATHAN
  • 依托单位:
CORE--SCIENTIFIC INSTRUMENT FACILITY
  • 批准号:
    6316509
  • 项目类别:
  • 资助金额:
    $28.96万
  • 财政年份:
    2000
  • 负责人:
    SANTHANAM SWAMINATHAN
  • 依托单位:
CORE--GLASSWARE AND STERILIZATION
  • 批准号:
    6316508
  • 项目类别:
  • 资助金额:
    $28.96万
  • 财政年份:
    2000
  • 负责人:
    SANTHANAM SWAMINATHAN
  • 依托单位:
CORE--GLASSWARE AND STERILIZATION
  • 批准号:
    6101621
  • 项目类别:
  • 资助金额:
    $28.96万
  • 财政年份:
    1999
  • 负责人:
    SANTHANAM SWAMINATHAN
  • 依托单位:
海外基金