EFFECTS OF ANOREXIA NERVOSA ON BONE METABOLISM IN FEMALE ADOLESCENTS

神经性厌食症对女性青少年骨代谢的影响

• 批准号: 6265449
• 负责人: STEVEN K. GRINSPOON
• 金额: $ 0.06万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6265449
• 关键词: adolescence (12-20); anorexia nervosa; bone metabolism; clinical research; estradiol; female; human subject; insulinlike growth factor; postnatal growth disorder

The objectives of this proposal are to define the impact of AN on bone turnover in adolescent females. We hypothesize that there is A) disordered bone metabolism in AN demonstrated by reduced biochemical markers of bone formation and/or increased markers of bone resorption B) abnormal peak bone mass accretion during puberty in AN subjects wherein BMD is reduced early in the disease and remains low even in late puberty, and C) the proposed low BMD and abnormal bone turnover in AN subjects during puberty can be correlated with low body mass index (BMI), disease severity, delayed skeletal maturation, and low levels of insulin-like growth factor 1 (IGF-1) and estradiol (E2).

这项建议的目的是确定AN对青春期女性骨转换的影响。我们假设，A)骨形成生化标记物减少和/或骨吸收标记物增加证明存在骨代谢紊乱；B)青春期骨密度在疾病早期降低并保持在低水平的受试者在青春期异常骨量增加，以及C)青春期受试者出现骨密度低和骨转换异常可能与低体重指数(BMI)、疾病严重程度、骨骼成熟延迟以及胰岛素样生长因子1(IGF-1)和雌二醇(E2)水平低有关。