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ISOLATION AND CHARACTERIZATION OF AUTOIMMUNE T CELL CLONES TO GAD65 IN IDDM

ISOLATION AND CHARACTERIZATION OF AUTOIMMUNE T CELL CLONES TO GAD65 IN IDDM
IDDM 中 GAD65 自身免疫 T 细胞克隆的分离和表征
批准号：
6119824
负责人：
STEINUNN BAEKKESKOV
金额：
$2.58万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6119824
关键词：
T lymphocyte autoantibody autoantigens clinical research disease /disorder prevention /control human subject immune tolerance /unresponsiveness insulin dependent diabetes mellitus leukocyte activation /transformation

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IDDM is the end result of autoimmune destruction of pancreatic B-cells in a process which progresses over many years. GAD65 has been identified as a major pancreatic B-cell target of autoantibodies. Such antibodies to GAD65 have been detected several years before clinical onset of IDDM, and therefore identify individuals at high risk of developing disease. We hypothesize that IDDM can be prevented by GAD65 specific immuno- intervention in susceptible individuals. The development of immunological tolerance requires analysis.
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