Development of a high-performance data storage and sharing platform for the NERC/NBAF genomics community.

为 NERC/NBAF 基因组学社区开发高性能数据存储和共享平台。

• 批准号: NE/L01288X/1
• 负责人: Karim Gharbi
• 金额: $ 18.11万
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FL01288X%2F1
• 关键词: Development; performance; data; storage; sharing

We propose hardware and software assets to implement a robust and secure infrastructure to store, archive, and share next-generation, high volume genomics data at collaborating nodes of the NERC Biomolecular Analysis Facilities in Liverpool and Edinburgh. The new e-infrastructure, built on existing core systems, will support a multi-tier storage architecture for: efficient data access for local processing; secure on-site storage; high-speed file transfer to the end user, to public repositories (e.g. European Nucleotide Archive) and to cloud computing resources (e.g. Cloud Bio-Linux); and fast data upload to NBAF servers. The assets will consist of network and server-attached storage, and industry leading Aspera file transfer technology to deliver speeds many times faster than FTP or HTTP.

我们提出硬件和软件资产，以实现一个强大而安全的基础设施，以存储，存档，并在利物浦和爱丁堡的NERC生物分子分析设施的协作节点共享下一代，高容量的基因组学数据。建立在现有核心系统基础上的新的电子基础设施将支持一个多层存储架构，用于：高效的数据访问，以进行本地处理;安全的现场存储;向最终用户、公共储存库（如欧洲核苷酸档案馆）和云计算资源（如Cloud Bio-Linux）的高速文件传输;以及向NBAF服务器的快速数据上传。这些资产将包括网络和服务器附加存储，以及行业领先的Aspera文件传输技术，其速度比FTP或HTTP快很多倍。

项目成果

Development of a Medium Density Combined-Species SNP Array for Pacific and European Oysters (Crassostrea gigas and Ostrea edulis).

• DOI: 10.1534/g3.117.041780
• 发表时间: 2017-07-05
• 期刊: G3 (Bethesda, Md.)
• 作者: Gutierrez AP;Turner F;Gharbi K;Talbot R;Lowe NR;Peñaloza C;McCullough M;Prodöhl PA;Bean TP;Houston RD
• 通讯作者: Houston RD

Dynamics of copy number variation in host races of the pea aphid.

• DOI: 10.1093/molbev/msu266
• 发表时间: 2015-01
• 期刊: Molecular biology and evolution
• 影响因子: 10.7
• 作者: Duvaux L;Geissmann Q;Gharbi K;Zhou JJ;Ferrari J;Smadja CM;Butlin RK
• 通讯作者: Butlin RK

Targeted re-sequencing confirms the importance of chemosensory genes in aphid host race differentiation.

• DOI: 10.1111/mec.13818
• 发表时间: 2017-01
• 期刊: Molecular ecology
• 影响因子: 4.9
• 作者: Eyres I;Duvaux L;Gharbi K;Tucker R;Hopkins D;Simon JC;Ferrari J;Smadja CM;Butlin RK
• 通讯作者: Butlin RK

Maintaining their genetic distance: Little evidence for introgression between widely hybridizing species of Geum with contrasting mating systems.

• DOI: 10.1111/mec.14426
• 发表时间: 2018-03
• 期刊: Molecular ecology
• 影响因子: 4.9
• 作者: Jordan CY;Lohse K;Turner F;Thomson M;Gharbi K;Ennos RA
• 通讯作者: Ennos RA

Dispersal in the sub-Antarctic: king penguins show remarkably little population genetic differentiation across their range.

• DOI: 10.1186/s12862-016-0784-z
• 发表时间: 2016-10-13
• 期刊: BMC evolutionary biology
• 影响因子: 3.4
• 作者: Clucas GV;Younger JL;Kao D;Rogers AD;Handley J;Miller GD;Jouventin P;Nolan P;Gharbi K;Miller KJ;Hart T
• 通讯作者: Hart T