CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE

阿片类药物和可卡因滥用临床研究中心

• 批准号: 2837847
• 负责人: THOMAS Richard KOSTEN
• 金额: $ 172.19万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-08-01 至 2000-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2837847
• 关键词: bioimaging /biomedical imaging; clinical research; cocaine; drug abuse; human subject; opiate alkaloid

This five year Center renewal builds on the neurobiology THEME of our previous nine years by examining the pathophysiology and treatment of cocaine and AIDS neurotoxicity. The Center projects range from preclinical neurobiology to human laboratory and clinical trials relevant to opioids and cocaine dependence, as well as HIV infection. During the last 5 years we have over 50 publications, 10 independent new grants, and substantial progress on all 7 projects. We now developed six new Major Projects for this Center renewal of which four are extensions of previous projects: 1. The HPA Axis and Neurobehavioral Effects of Cocaine, 2. Glucocorticoid Function in Cocaine Dependence, 3. SPECT and Microdialysis Measurements of Cocaine Abuse, 4,Lamotrigine for Cocaine Abuse in HIV+Patients. Two new projects have evolved from our pilot work and collaborations with both the General Medical Clinical Research Center and the AIDS Clinical Trials Unit at Yale: 5. Amiloride for Cocaine Associated Cerebral Perfusion Deficits, 6. Opiate Dependence Pharmacotherapy Effects on AIDS Antiviral medications. The CORE will continue to support collaborations with these other research Centers at Yale, to integrate across the Center's Major Projects and investigators, and to conduct 2-3 pilot studies per year with a focus on AIDS related treatments and neurobiology. These pilots include cortisol levels in early AIDS patients on methadone treatment and neuroimaging in AIDS patients with cognitive impairment.

这个为期五年的中心更新建立在我们的神经生物学主题上

项目成果

Dynamic SPECT imaging of dopamine D2 receptors in human subjects with iodine-123-IBZM.

使用 iodine-123-IBZM 对人体多巴胺 D2 受体进行动态 SPECT 成像。

• 发表时间: 1992
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Seibyl,JP;Woods,SW;Zoghbi,SS;Baldwin,RM;Dey,HM;Goddard,AW;Zea-Ponce,Y;Zubal,G;Germine,M;Smith,EO
• 通讯作者: Smith,EO

Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure.

可卡乙烯预暴露后对可卡因运动激活作用的敏感性。

• DOI: 10.1016/0006-8993(96)00783-4
• 发表时间: 1996
• 期刊: Brain research
• 影响因子: 2.9
• 作者: Horger,BA;Taylor,JR;Elsworth,JD;Jatlow,PI;Roth,RH
• 通讯作者: Roth,RH

Long-term haloperidol administration enhances and short-term administration attenuates the behavioral effects of cocaine in a place conditioning procedure.

长期施用氟哌啶醇可增强而短期施用可减弱可卡因在场所调理过程中的行为影响。

• DOI: 10.1007/s002130050138
• 发表时间: 1996
• 期刊: Psychopharmacology
• 影响因子: 3.4
• 作者: Kosten,TA;DeCaprio,JL;Nestler,EJ
• 通讯作者: Nestler,EJ

Evaluation of a point-of-care testing product for drugs of abuse; testing site is a key variable.

评估滥用药物的即时检测产品；

• DOI: 10.1016/0376-8716(95)01188-9
• 发表时间: 1995
• 期刊: Drug and alcohol dependence
• 影响因子: 4.2
• 作者: Kranzler,HR;Stone,J;McLaughlin,L
• 通讯作者: McLaughlin,L

Desipramine facilitation of initial cocaine abstinence.

地昔帕明促进最初的可卡因戒断。

• DOI: 10.1001/archpsyc.1989.01810020019004
• 发表时间: 1989
• 期刊: Archives of general psychiatry
• 作者: Gawin,FH;Kleber,HD;Byck,R;Rounsaville,BJ;Kosten,TR;Jatlow,PI;Morgan,C
• 通讯作者: Morgan,C