CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
CLINICAL RESEARCH CENTER FOR OPIOID AND COCAINE ABUSE
批准号:
2837847
负责人:
THOMAS Richard KOSTEN
金额:
$172.19万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-08-01 至 2000-11-30
中文摘要
点击翻译按钮获取中文摘要
英文摘要
This five year Center renewal builds on the neurobiology THEME of our
previous nine years by examining the pathophysiology and treatment of
cocaine and AIDS neurotoxicity. The Center projects range from preclinical
neurobiology to human laboratory and clinical trials relevant to opioids
and cocaine dependence, as well as HIV infection. During the last 5 years
we have over 50 publications, 10 independent new grants, and substantial
progress on all 7 projects. We now developed six new Major Projects for
this Center renewal of which four are extensions of previous projects: 1.
The HPA Axis and Neurobehavioral Effects of Cocaine, 2. Glucocorticoid
Function in Cocaine Dependence, 3. SPECT and Microdialysis Measurements of
Cocaine Abuse, 4,Lamotrigine for Cocaine Abuse in HIV+Patients. Two new
projects have evolved from our pilot work and collaborations with both the
General Medical Clinical Research Center and the AIDS Clinical Trials Unit
at Yale: 5. Amiloride for Cocaine Associated Cerebral Perfusion Deficits,
6. Opiate Dependence Pharmacotherapy Effects on AIDS Antiviral
medications. The CORE will continue to support collaborations with these
other research Centers at Yale, to integrate across the Center's Major
Projects and investigators, and to conduct 2-3 pilot studies per year with
a focus on AIDS related treatments and neurobiology. These pilots include
cortisol levels in early AIDS patients on methadone treatment and
neuroimaging in AIDS patients with cognitive impairment.
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Dynamic SPECT imaging of dopamine D2 receptors in human subjects with iodine-123-IBZM.
使用 iodine-123-IBZM 对人体多巴胺 D2 受体进行动态 SPECT 成像。
DOI:
--
发表时间:
1992
期刊:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子:
--
作者:
[Seibyl,JP, Woods,SW, Zoghbi,SS, Baldwin,RM, Dey,HM, Goddard,AW, Zea-Ponce,Y, Zubal,G, Germine,M, Smith,EO]
通讯作者:
Smith,EO
Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure.
可卡乙烯预暴露后对可卡因运动激活作用的敏感性。
DOI:
10.1016/0006-8993(96)00783-4
发表时间:
1996
期刊:
Brain research
影响因子:
2.9
作者:
[Horger,BA, Taylor,JR, Elsworth,JD, Jatlow,PI, Roth,RH]
通讯作者:
Roth,RH
Long-term haloperidol administration enhances and short-term administration attenuates the behavioral effects of cocaine in a place conditioning procedure.
长期施用氟哌啶醇可增强而短期施用可减弱可卡因在场所调理过程中的行为影响。
DOI:
10.1007/s002130050138
发表时间:
1996
期刊:
Psychopharmacology
影响因子:
3.4
作者:
[Kosten,TA, DeCaprio,JL, Nestler,EJ]
通讯作者:
Nestler,EJ
Evaluation of a point-of-care testing product for drugs of abuse; testing site is a key variable.
评估滥用药物的即时检测产品;
DOI:
10.1016/0376-8716(95)01188-9
发表时间:
1995
期刊:
Drug and alcohol dependence
影响因子:
4.2
作者:
[Kranzler,HR, Stone,J, McLaughlin,L]
通讯作者:
McLaughlin,L
Desipramine facilitation of initial cocaine abstinence.
地昔帕明促进最初的可卡因戒断。
DOI:
10.1001/archpsyc.1989.01810020019004
发表时间:
1989
期刊:
Archives of general psychiatry
影响因子:
--
作者:
[Gawin,FH, Kleber,HD, Byck,R, Rounsaville,BJ, Kosten,TR, Jatlow,PI, Morgan,C]
通讯作者:
Morgan,C
共 108 条
Human methamphetamine vaccine: Translational Avante Garde Award
-
批准号:8289239
-
项目类别:
-
资助金额:$78.25万
-
财政年份:2011
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Human methamphetamine vaccine: Translational Avante Garde Award
-
批准号:9137114
-
项目类别:
-
资助金额:$6.4万
-
财政年份:2011
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Human methamphetamine vaccine: Translational Avante Garde Award
-
批准号:8724467
-
项目类别:
-
资助金额:$78.25万
-
财政年份:2011
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Human methamphetamine vaccine: Translational Avante Garde Award
-
批准号:8540992
-
项目类别:
-
资助金额:$75.12万
-
财政年份:2011
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Human methamphetamine vaccine: Translational Avante Garde Award
-
批准号:8334706
-
项目类别:
-
资助金额:$78.25万
-
财政年份:2011
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Human methamphetamine vaccine: Translational Avante Garde Award
-
批准号:8913925
-
项目类别:
-
资助金额:$77.08万
-
财政年份:2011
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Developing Immunotherapeutics for Methamphetamine Abuse
-
批准号:7340807
-
项目类别:
-
资助金额:$69.69万
-
财政年份:2009
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Methadone Studies
-
批准号:7761495
-
项目类别:
-
资助金额:$27.76万
-
财政年份:2009
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Multisite Controlled Trial of Cocaine Vaccine (1of 6) Lead Site/ Houston Treatmen
-
批准号:7513380
-
项目类别:
-
资助金额:$47.81万
-
财政年份:2008
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Administrative and Scientific Core
-
批准号:7701058
-
项目类别:
-
资助金额:$28.79万
-
财政年份:2008
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Multisite Controlled Trial of Cocaine Vaccine (1of 6) Lead Site/ Houston Treatmen
-
批准号:7685479
-
项目类别:
-
资助金额:$58.69万
-
财政年份:2008
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Multisite Controlled Trial of Cocaine Vaccine (1of 6) Lead Site/ Houston Treatmen
-
批准号:8215788
-
项目类别:
-
资助金额:$47.6万
-
财政年份:2008
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Multisite Controlled Trial of Cocaine Vaccine (1of 6) Lead Site/ Houston Treatmen
-
批准号:8271726
-
项目类别:
-
资助金额:$13.62万
-
财政年份:2008
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Tropisetron with Risperidone for Schizophrenia
-
批准号:7225758
-
项目类别:
-
资助金额:$28.41万
-
财政年份:2007
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Tropisetron with Risperidone for Schizophrenia
-
批准号:7364160
-
项目类别:
-
资助金额:$26.86万
-
财政年份:2007
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Tropisetron with Risperidone for Schizophrenia
-
批准号:7582406
-
项目类别:
-
资助金额:$27.39万
-
财政年份:2007
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
PHARMACOTHERAPIES OF COCAINE ADDICTION IN HUMANS
-
批准号:7459050
-
项目类别:
-
资助金额:$10.84万
-
财政年份:2007
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Kappa Opioid Antagonist for Cocaine Addiction
-
批准号:7495038
-
项目类别:
-
资助金额:$43.99万
-
财政年份:2007
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Administrative and Scientific Core
-
批准号:7514100
-
项目类别:
-
资助金额:$46.21万
-
财政年份:2007
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
Kappa Opioid Antagonist for Cocaine Addiction
-
批准号:7085669
-
项目类别:
-
资助金额:$0.0万
-
财政年份:2005
-
负责人:THOMAS Richard KOSTEN
-
依托单位:
海外基金