EVALUATION OF CARCINOGENIC RISKS

致癌风险评估

• 批准号: 2376770
• 负责人: JERRY M RICE
• 金额: $ 68.37万
• 依托单位: INTERNATIONAL AGENCY FOR RES ON CANCER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 2000-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2376770
• 关键词: cancer risk; carcinogen testing; chemical carcinogen; chemical information system; health science research analysis /evaluation; information dissemination; international health /scientific organization; literature survey; monograph

The objective of the IARC Program on the Evaluation of Carcinogenic Risks to Humans is to identify on the basis of all published epidemiological and experimental data exposures to chemicals, complex mixtures, and physical and biological factors and exposure circumstances which may pose a carcinogenic risk to humans, and to publish these evaluated data in the form of IARC Monographs. The Preamble to the IARC Monographs defines the guiding principles in making evaluations of carcinogenicity on the basis of results from epidemiological studies, long-term carcinogenicity studies in animals and other relevant data (e.g., toxicity, metabolism, genotoxicity and mechanistic studies). Priorities for future monographs topics have been established by ad-hoc Working Groups. Since new topics for evaluation will be chosen in part on the basis of future publication of experimental findings, the program also monitors on-going carcinogenicity testing worldwide through the Directory of Agents Being Tested for Carcinogenicity. A Directory of On-Going Research on Cancer Epidemiology is also produced by the Agency. Each volume of IARC Monographs results from the deliberations of an international Working Group of 15-20 experts in epidemiology, experimental carcinogenesis and related disciplines which meets in Lyon for one week; three meetings are held each year. Monographs are distributed to Governments, Regulatory Agencies and interested scientists; they are available via the WHO Distribution and Sales Service. The summarized and evaluated data can be used as an element on which priorities for preventive measures will be decided. The Monographs and related databases will also be available on an IARCancer CD-ROM. The Directory is produced every two years based upon the replies received to survey questionnaires. They are distributed to all collaborating laboratories and governments with the aim of reducing duplication of effort and improving communication between scientists in the area of carcinogenicity testing in animals. The International Agency for Research on Cancer has adequate facilities for meetings and the production of monographs. Scientific staff includes scientists from many different countries who can assist in the evaluation of international scientific literature and provide scientific guidance for the Working Groups.

IARC致癌风险评估计划的目标 是根据所有已发表的流行病学和 实验数据暴露于化学品、复杂混合物和物理 生物因素和接触环境， 对人类的致癌风险，并将这些评估数据公布在 IARC Monographs的形式。 IARC专论的序言定义了 致癌性评价的指导原则 流行病学研究、长期致癌性研究 在动物和其他相关数据中（例如，毒性，代谢， 遗传毒性和机制研究）。 未来各论的优先事项 专题由特设工作组确定。 由于新的主题 将根据未来的出版物部分选择评估 实验结果，该计划还监测正在进行的 全球致癌性测试通过代理目录 进行致癌性试验。 正在进行的癌症研究目录 该机构还编制流行病学报告。 每卷IARC专著都是由一个 由15-20名流行病学专家组成的国际工作组， 在里昂举行为期一周的致癌作用和相关学科会议; 每年举行三次会议。专著分发给 政府、监管机构和感兴趣的科学家;他们是 可通过世卫组织分发和销售处获得。 总结和 评估的数据可以用作元素， 将采取预防措施。 专著和相关数据库 也将在IARCancer CD-ROM上提供。 该名录每两年根据收到的答复编制一次 调查问卷。它们被分发给所有合作的 实验室和政府，目的是减少重复 加强科学家之间的交流 动物致癌性试验。 国际癌症研究机构有足够的设施， 用于会议和编写专著。 科研人员包括 来自许多不同国家的科学家可以协助评估 国际科学文献，并提供科学指导， 工作组。