EVALUATION OF CARCINOGENIC RISKS

国际癌症研究机构致癌风险评估项目的目标 对人类来说就是根据所有已发表的流行病学和 接触化学物质、复杂混合物和物理物质的实验数据 生物因素和暴露环境可能构成 对人类的致癌风险，并将这些评估数据发表在 IARC专著的形式。IARC专著的序言定义了 按标准进行致癌性评价的指导原则 流行病学研究、长期致癌性研究的结果 动物和其他相关数据(例如，毒性、新陈代谢、 遗传毒性和机制研究)。未来专著的优先事项 特设工作组已确定了专题。因为有新的话题 将部分根据未来的出版情况来选择评价对象 对于实验结果，该程序还监控正在进行的 通过代理商名录进行全球致癌性测试 做了致癌测试。正在进行的癌症研究目录 流行病学也是由该机构制作的。 IARC专著的每一卷都是由一个 由15-20名实验性流行病学专家组成的国际工作组 癌变及相关学科在里昂举行为期一周的会议； 每年举行三次会议。专著分发到 政府、监管机构和感兴趣的科学家；他们 可通过世卫组织分发和销售服务获得。摘要和 评估的数据可以用作优先考虑的元素 将决定预防措施。专著及相关数据库 也将在IAR癌症CD-ROM上提供。 根据收到的答复，每两年编制一次目录 对调查问卷进行调查。它们将分发给所有合作伙伴 实验室和政府，目的是减少重复使用 努力和改善科学家在以下领域的交流 动物致癌性测试。 国际癌症研究机构有足够的设施 用于会议和专著的出版。科研人员包括 来自许多不同国家的科学家，他们可以协助评估 收集国际科学文献，并为 工作组。

The objective of the IARC Program on the Evaluation of Carcinogenic Risks to Humans is to identify on the basis of all published epidemiological and experimental data exposures to chemicals, complex mixtures, and physical and biological factors and exposure circumstances which may pose a carcinogenic risk to humans, and to publish these evaluated data in the form of IARC Monographs. The Preamble to the IARC Monographs defines the guiding principles in making evaluations of carcinogenicity on the basis of results from epidemiological studies, long-term carcinogenicity studies in animals and other relevant data (e.g., toxicity, metabolism, genotoxicity and mechanistic studies). Priorities for future monographs topics have been established by ad-hoc Working Groups. Since new topics for evaluation will be chosen in part on the basis of future publication of experimental findings, the program also monitors on-going carcinogenicity testing worldwide through the Directory of Agents Being Tested for Carcinogenicity. A Directory of On-Going Research on Cancer Epidemiology is also produced by the Agency. Each volume of IARC Monographs results from the deliberations of an international Working Group of 15-20 experts in epidemiology, experimental carcinogenesis and related disciplines which meets in Lyon for one week; three meetings are held each year. Monographs are distributed to Governments, Regulatory Agencies and interested scientists; they are available via the WHO Distribution and Sales Service. The summarized and evaluated data can be used as an element on which priorities for preventive measures will be decided. The Monographs and related databases will also be available on an IARCancer CD-ROM. The Directory is produced every two years based upon the replies received to survey questionnaires. They are distributed to all collaborating laboratories and governments with the aim of reducing duplication of effort and improving communication between scientists in the area of carcinogenicity testing in animals. The International Agency for Research on Cancer has adequate facilities for meetings and the production of monographs. Scientific staff includes scientists from many different countries who can assist in the evaluation of international scientific literature and provide scientific guidance for the Working Groups.