EVALUATION OF CARCINOGENIC RISKS TO HUMANS

国际癌症研究机构评估人类致癌风险专著规划的目标是严格审查和评估已发表的关于生物、物理和化学制剂、复杂混合物以及人类暴露环境的致癌风险的全部科学证据的强度，并将这些审查和评估以书籍形式作为国际癌症研究机构的专著出版。长期目标是对导致人类癌症的所有重要环境因素进行评估，并对那些在最初评估时证据不完整的因素进行重新评估，只要新的发现提供了可能改变先前评估的额外证据。近期的另一个目标是以完整的、可检索的电子版本补充现有的硬拷贝出版物，这些电子版将通过互联网联机提供并作为CD-ROM提供。《国际癌症研究机构专著》的序言规定了在流行病学研究、实验动物致癌性生物测定和其他相关数据（如毒性、代谢、遗传毒理学和致癌物作用机制）的基础上进行致癌性评价的指导原则。评估提名在全世界征求，并由科学和公共卫生专家特设国际咨询小组每隔大约五年确定优先次序和优先次序。规划主办关于致癌机制和与致癌性评价有关的其他主题的科学会议，并（在互联网上以电子形式）出版《世界范围内正在进行致癌性试验的物质目录》，以促进科学家之间的交流并减少不必要的重复工作。国际癌症研究机构专著的每一卷都是由来自8-12个国家的202-25名癌症流行病学、实验致癌和相关学科专家组成的国际工作组审议的结果，该工作组在里昂举行为期一周的会议；每年召开三次会议。这些专著作为已发表文献的权威摘要，对科学家和公共卫生官员很有价值；作为风险评估、风险管理和风险管理举措的信息来源之一；并给私人个人作为可靠的参考文本。

The objectives of the IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans are to critically review and evaluate the strength of the total published scientific evidence for carcinogenic risk from biological, physical, and chemical agents, complex mixtures, and exposure circumstances to which humans are exposed, and to publish these reviews and evaluations in book form as IARC Monographs. The long-term goal is to provide evaluations of all significant environmental contributing causes of human cancer, and to re-evaluate those for which evidence is incomplete at the time of initial evaluation whenever new findings provide additional evidence which may change a previous evaluation. A further goal for the immediate future that is to supplement the existing hard-copy publications by complete, searchable electronic versions that will be available both on-line by internet and as CD-ROM. The Preamble to the IARC Monographs defines the guiding principles for making evaluations of carcinogenicity on the basis of epidemiologic studies, bioassays for carcinogenicity in experimental animals, and other relevant data (e.g., toxicity, metabolism, genetic toxicology, and mechanisms of carcinogen action). Nominations for evaluations are solicited worldwide and prioritized and prioritized by ad-hoc international advisory groups of scientific and public health experts at intervals of approximately five years. The Programme sponsors scientific meetings on carcinogenic mechanisms and other subjects relevant to evaluations of carcinogenicity, and publishes (in electronic form on the Internet) a Directory of Agents being Tested for Carcinogenicity worldwide, to facilitate communication among scientists and to reduce unnecessary duplication of effort. Each volume of the IARC Monographs results from the deliberations of an international working group of 202-25 experts in cancer epidemiology, experimental carcinogenesis and related disciplines from 8-12 countries which meets in Lyon for one week; three meetings are held each year. The Monographs are of value to scientists and public health officials as authoritative summaries of the published literature; to regulatory authorities as one source of information on which to base risk assessments and risk management and risk management initiatives; and to private individuals as a reliable reference text.