EVALUATION OF CARCINOGENIC RISKS TO HUMANS

人类致癌风险评估

• 批准号: 6134797
• 负责人: JERRY M RICE
• 金额: $ 63.63万
• 依托单位: INTERNATIONAL AGENCY FOR RES ON CANCER
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6134797
• 关键词: DVD /CD ROM; Internet; animal data; cancer risk; carcinogen testing; chemical carcinogen; chemical information system; cooperative study; environmental exposure; human data; information dissemination; international health /scientific organization; literature survey; monograph

The objectives of the IARC Monographs Programme on the Evaluation of Carcinogenic Risks to Humans are to critically review and evaluate the strength of the total published scientific evidence for carcinogenic risk from biological, physical, and chemical agents, complex mixtures, and exposure circumstances to which humans are exposed, and to publish these reviews and evaluations in book form as IARC Monographs. The long-term goal is to provide evaluations of all significant environmental contributing causes of human cancer, and to re-evaluate those for which evidence is incomplete at the time of initial evaluation whenever new findings provide additional evidence which may change a previous evaluation. A further goal for the immediate future that is to supplement the existing hard-copy publications by complete, searchable electronic versions that will be available both on-line by internet and as CD-ROM. The Preamble to the IARC Monographs defines the guiding principles for making evaluations of carcinogenicity on the basis of epidemiologic studies, bioassays for carcinogenicity in experimental animals, and other relevant data (e.g., toxicity, metabolism, genetic toxicology, and mechanisms of carcinogen action). Nominations for evaluations are solicited worldwide and prioritized and prioritized by ad-hoc international advisory groups of scientific and public health experts at intervals of approximately five years. The Programme sponsors scientific meetings on carcinogenic mechanisms and other subjects relevant to evaluations of carcinogenicity, and publishes (in electronic form on the Internet) a Directory of Agents being Tested for Carcinogenicity worldwide, to facilitate communication among scientists and to reduce unnecessary duplication of effort. Each volume of the IARC Monographs results from the deliberations of an international working group of 202-25 experts in cancer epidemiology, experimental carcinogenesis and related disciplines from 8-12 countries which meets in Lyon for one week; three meetings are held each year. The Monographs are of value to scientists and public health officials as authoritative summaries of the published literature; to regulatory authorities as one source of information on which to base risk assessments and risk management and risk management initiatives; and to private individuals as a reliable reference text.

IARC人类致癌风险评估专著计划的目标是严格审查和评估生物、物理和化学制剂、复杂混合物以及人类暴露的暴露环境的致癌风险的全部已发表科学证据的强度，并以书籍形式将这些审查和评估作为IARC专著出版。长期目标是提供对人类癌症的所有重要环境成因的评估，并在新发现提供可能改变先前评估的额外证据时重新评估那些在初步评估时证据不完整的环境成因。近期的另一个目标是通过互联网在线和CD-ROM提供完整的、可搜索的电子版本来补充现有的硬拷贝出版物。IARC专论的序言定义了在流行病学研究、实验动物致癌性生物测定和其他相关数据（例如，毒性、代谢、遗传毒理学和致癌作用机制）。在世界范围内征求评价提名，并由科学和公共卫生专家特设国际咨询小组每隔大约五年确定优先次序。该方案主办关于致癌机制和与评价致癌性有关的其他主题的科学会议，并（以电子形式在因特网上）出版一份《全世界正在进行致癌性试验的制剂目录》，以便利科学家之间的交流，减少不必要的重复工作。IARC的每一卷专著都是由来自8-12个国家的202-25名癌症流行病学、实验致癌作用和相关学科专家组成的国际工作组审议的结果，该工作组在里昂举行为期一周的会议;每年举行三次会议。这些专著对科学家和公共卫生官员具有价值，可作为已发表文献的权威性摘要;对管理当局具有价值，可作为风险评估和风险管理及风险管理举措的信息来源;对个人具有价值，可作为可靠的参考文本。