CORE--ENGINEERING

热疗技术是复杂和快速发展的。临床 治疗不一定是常规的，因为治疗可以是 交付时不考虑可用的技术限制 供暖方式和相关设备。因此，物理学/工程学 对治疗决策的投入是必不可少的。此外，深入了解 技术创新只能来自技术的存在 临床上的专业知识。最后，需要这种专业知识来开发 并测试新技术。工程核心的目标是提供 为该计划中的研究项目提供技术支持。这一支持 在三个具体目标下定义：1)技术支持和QA PI、PII、Pill的临床方案。2)设备的开发 诱导和监测体温过高。3)数字支持验证 PIV中的模特。4)研制功能齐全的热疗设备 与磁共振成像(MRI)和磁共振兼容 光谱分析(MRS)。目的L本质上是一个临床质量保证问题 由核心人员的积极在场在 临床治疗。目标2的主要关注点将借鉴过去的临床经验 开发区域和本地联合供热系统的经验。这 系统和血管活性药物将在PLL中测试策略 通过减少热量实现更高和更均匀的局部温度 由于血液流动造成的损失。目标3提供核心的积极参与 电力数值模型的前瞻性和回溯性检验 PIV中的沉积和热分布。主要目标5 将测试化学位移磁共振用于非侵入性治疗的可行性 测温仪。初步数据表明，这项技术可以提供 梯度回波相位图中的期望温度和空间分辨率 在热疗过程中获得的。此外，MRI和MRS研究还包括 为本计划中的所有项目和工程核心进行规划 将根据需要从技术上支持这些努力。

Technology in hyperthermia is complex and rapidly evolving. Clinical treatments are not necessarily routine in the sense that therapy can be delivered without consideration of the technical limitations of available heating modalities and associated equipment. Thus, physics/engineering input into treatment decisions are essential. Also, insight into technological innovations can only come from a presence of technical expertise in the clinic. Finally, this expertise is required to develop and test new technologies. The goal of the engineering core is to provide technical support for the research projects in this program. This support is defined under three specific aims: 1) Technical support and QA for clinical protocols in PI, PII, Pill. 2) Development of equipment for inducing and monitoring hyperthermia. 3) Support verifications numerical models in PIV. 4) Develop hyperthermia equipment having functional compatibility with magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in PV. Aim l is essentially a QA issue for clinical protocols that is addressed by an active presence of core personnel during clinical treatments. The primary focus of Aim 2 will draw on past clinical experience to develop a combined regional and local heating system. This system together with vasoactive agents will test strategies in Pll for achieving higher and more uniform local temperatures by reducing heat losses due to blood flow. Aim 3 provides active participation of the core in prospective and retrospective testing of numerical models of power deposition and thermal distributions respectively in PIV. Aim 5 primarily will test the feasibility of using Chemical Shift MRI for non-invasive thermometry. Preliminary data indicate that this technique can provide desired temperature and spatial resolution in gradient echo phase images obtained during hyperthermia. Additionally, MRI and MRS studies are planned for all of the projects in this program and the engineering core will technically support these efforts as required.