NONINVASIVE THERMOMETRY

该项目（项目1）的长期目标是实现磁共振成像（MRI）， 在最具侵袭性的局部晚期肿瘤的热疗治疗期间监测温度。在这 建议重点关注四肢、乳腺或骨盆/腹部的肿瘤。在以前的工作中， 当然，我们已经证明，磁共振成像可以有效和准确地显示组织中的温度变化 与非电离辐射的吸收有关。热、空间和时间分辨率 用MRI实现的温度范围随治疗应用而变化，但它们通常在0.5 - 1.0 ℃、 1.0 cm 3体素尺寸，以及6 - 20秒的测量采集时间。这些分辨率范围意味着， MRI作为一种非侵入性的工具，在热成像技术的发展和应用中可以发挥重要作用。 治疗能量吸收率、沉积（ARD）和温度是用于测量能量吸收率的重要度量。 非侵入式测温的整体准确性和成功率，以及 电源控制（项目2）。这两个参数都将在本项目中进行测量。特别是， 总体假设：磁共振成像可用于无创监测ARD和温度 遍布肿瘤和周围正常组织我们将使用 具体目标如下： 具体目标1：为临床应用开发强大的MRI热成像技术。 特定目标2：在热疗治疗期间进行三维MRI温度监测， 患有下肢或乳房肿瘤的患者。 特定目标3：在热疗治疗期间进行三维MRI温度监测， 患有下腹部和骨盆肿瘤的患者 结合项目2中开发的工具，来自MRI的温度数据将首次实现3- 在临床重要治疗情况下的热剂量尺寸控制。

The long-term goal of this project (Project 1) is to implement magnetic resonance imaging (MRI) to monitor temperature during hyperthermia treatment of the most aggressive locally advanced tumors. In this proposal the focus will be on tumors of the extremities, breast or pelvis/abdomen,. In previous work on this grant, we have shown that MRI can be effective and accurate for visualizing temperature changes in tissues associated with the absorption of nonionizing radiation. The thermal, spatial and temporal resolutions achieved with MRI vary with the therapeutic applications, but they are generally in the ranges 0.5-1.0'C, 0.5- 1.0 cm3 voxel size, and 6-20 seconds measurement acquisition time. These resolution ranges imply that MRI can play an important role as a non-invasive tool in the development and application of thermal therapies. Energy absorption rate deposition (ARD) and temperature are important metrics for gauging the overall accuracy and success of non-invasive thermometry and for implementation of control algorithms for power control (Project 2). Both of these parameters will be measured in this project. In particular, we pose the overall hypothesis that: Magnetic resonance imaging can be used to monitor ARD and temperature noninvasively throughout the tumor and surrounding normal tissue. We will test this hypothesis using the following specific aims: SPECIFIC AIM 1: Develop robust MRI thermal imaging techniques for clinical applications. SPECIFIC AIM 2: Perform 3-dimensional MRI temperature monitoring during hyperthermia treatment in patients having tumors of the lower extremity or breast. SPECIFIC AIM 3: Perform 3-dimensional MRI temperature monitoring during hyperthermia treatment in patients having tumors of the lower abdomen and pelvis Combined with the tools developed in Project 2, temperature data from MRI will, for the first time, enable 3- dimensional control of thermal dose in clinically important treatment situations.