CORE--ENGINEERING

核心--工程

• 批准号: 6102310
• 负责人: THADDEUS V. SAMULSKI
• 金额: $ 28.07万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-08-01 至 1999-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6102310
• 关键词: bioengineering /biomedical engineering; biomedical facility; model design /development; neoplasm /cancer thermotherapy; technology /technique development; thermometry

Technology in hyperthermia is complex and rapidly evolving. Clinical treatments are not necessarily routine in the sense that therapy can be delivered without consideration of the technical limitations of available heating modalities and associated equipment. Thus, physics/engineering input into treatment decisions are essential. Also, insight into technological innovations can only come from a presence of technical expertise in the clinic. Finally, this expertise is required to develop and test new technologies. The goal of the engineering core is to provide technical support for the research projects in this program. This support is defined under three specific aims: 1) Technical support and QA for clinical protocols in PI, PII, Pill. 2) Development of equipment for inducing and monitoring hyperthermia. 3) Support verifications numerical models in PIV. 4) Develop hyperthermia equipment having functional compatibility with magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in PV. Aim l is essentially a QA issue for clinical protocols that is addressed by an active presence of core personnel during clinical treatments. The primary focus of Aim 2 will draw on past clinical experience to develop a combined regional and local heating system. This system together with vasoactive agents will test strategies in Pll for achieving higher and more uniform local temperatures by reducing heat losses due to blood flow. Aim 3 provides active participation of the core in prospective and retrospective testing of numerical models of power deposition and thermal distributions respectively in PIV. Aim 5 primarily will test the feasibility of using Chemical Shift MRI for non-invasive thermometry. Preliminary data indicate that this technique can provide desired temperature and spatial resolution in gradient echo phase images obtained during hyperthermia. Additionally, MRI and MRS studies are planned for all of the projects in this program and the engineering core will technically support these efforts as required.

热疗技术是复杂和快速发展的。临床 治疗不一定是常规的， 不考虑现有技术的局限性， 加热方式和相关设备。物理/工程 对治疗决定的投入至关重要。此外， 技术创新只能来自技术的存在， 在诊所的专业知识。最后，需要这种专门知识来发展 测试新技术。 工程核心的目标是提供 为该项目的研究项目提供技术支持。这种支持 根据三个具体目标确定：1）技术支持和质量保证， PI、PII、Pill的临床方案。2)设备的研制 诱导和监测体温过高。3)支持数字验证 PIV模型4)开发具有功能的热疗设备 与磁共振成像（MRI）和磁共振成像的兼容性 磁共振波谱（MRS）在PV中的应用目标1基本上是临床的QA问题 核心人员的积极参与， 临床治疗。目标2的主要重点将借鉴过去的临床经验， 开发区域和局部供暖系统的经验。 这 系统与血管活性剂一起将测试PII中的策略， 通过减少热量来实现更高和更均匀的局部温度 由于血液流动的损失。目标3：核心积极参与 在权力的数字模型的前瞻性和回顾性测试中， 沉积和热分布分别在PIV。第5章主要 将测试使用化学位移MRI进行非侵入性检查的可行性 温度测定法初步数据表明，这项技术可以提供 梯度回波相位图像中的期望温度和空间分辨率 在高温下获得的。此外，MRI和MRS研究是 计划用于本计划中的所有项目和工程核心 将根据需要为这些努力提供技术支持。