NONINVASIVE THERMOMETRY

该项目(项目1)的长期目标是实现磁共振成像(MRI)以 在最具侵袭性的局部晚期肿瘤的热疗过程中监测温度。在这 建议将重点放在四肢、乳腺或骨盆/腹部的肿瘤上。在以前关于这一点的工作中 格兰特，我们已经证明MRI可以有效和准确地显示组织中的温度变化 与非电离辐射的吸收有关。热分辨率、空间分辨率和时间分辨率 磁共振成像获得的结果因治疗应用的不同而不同，但它们通常在0.5-1.0℃、0.5-1.0℃、0.5-1.0℃的范围内。 体素大小为1.0 cm3，测量采集时间为6-20秒。这些分辨率范围意味着 MRI作为一种非侵入性工具，可以在热疗的发展和应用中发挥重要作用 治疗。能量吸收速率沉积(ARD)和温度是测量 非侵入性测温的总体准确性和成功以及控制算法的实施 电源控制(项目2)。这两个参数都将在本项目中进行测量。特别是，我们摆出了 总体假设是：磁共振成像可用于无创监测ARD和体温 遍及整个肿瘤和周围的正常组织。我们将使用 以下是具体目标： 具体目标1：为临床应用开发健壮的MRI热成像技术。 特定目的2：在热疗过程中进行三维磁共振体温监测 患有下肢或乳房肿瘤的患者。 特定目的3：在热疗过程中进行三维磁共振体温监测 患有下腹部和骨盆肿瘤的患者 结合项目2中开发的工具，来自MRI的温度数据将首次实现3- 临床重要治疗情况下热剂量的维度控制。

The long-term goal of this project (Project 1) is to implement magnetic resonance imaging (MRI) to monitor temperature during hyperthermia treatment of the most aggressive locally advanced tumors. In this proposal the focus will be on tumors of the extremities, breast or pelvis/abdomen,. In previous work on this grant, we have shown that MRI can be effective and accurate for visualizing temperature changes in tissues associated with the absorption of nonionizing radiation. The thermal, spatial and temporal resolutions achieved with MRI vary with the therapeutic applications, but they are generally in the ranges 0.5-1.0'C, 0.5- 1.0 cm3 voxel size, and 6-20 seconds measurement acquisition time. These resolution ranges imply that MRI can play an important role as a non-invasive tool in the development and application of thermal therapies. Energy absorption rate deposition (ARD) and temperature are important metrics for gauging the overall accuracy and success of non-invasive thermometry and for implementation of control algorithms for power control (Project 2). Both of these parameters will be measured in this project. In particular, we pose the overall hypothesis that: Magnetic resonance imaging can be used to monitor ARD and temperature noninvasively throughout the tumor and surrounding normal tissue. We will test this hypothesis using the following specific aims: SPECIFIC AIM 1: Develop robust MRI thermal imaging techniques for clinical applications. SPECIFIC AIM 2: Perform 3-dimensional MRI temperature monitoring during hyperthermia treatment in patients having tumors of the lower extremity or breast. SPECIFIC AIM 3: Perform 3-dimensional MRI temperature monitoring during hyperthermia treatment in patients having tumors of the lower abdomen and pelvis Combined with the tools developed in Project 2, temperature data from MRI will, for the first time, enable 3- dimensional control of thermal dose in clinically important treatment situations.