CONDITIONING AND BONDING AGENTS FOR RESIN BASED COMPOSITES

树脂基复合材料的调理剂和粘合剂

• 批准号: 6238459
• 负责人: KARL-JOHAN M SODERHOLM
• 金额: $ 19.54万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-29 至 1998-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6238459
• 关键词: biomaterial development /preparation; biomaterial interface interaction; composite resins; dental adhesive /sealant; dental bonding material; dentin; tooth filling

The search for the ideal material for restorative dentistry has recently focused on the development and analysis of dentin bonding agents that bond to conditioned dentin and that are hydrolytically stable. Conflicting and quite variable results have been reported on the bond strength of these agents to conditioned dentin. The overall objective of this proposal is to develop a dentinal bonding agent-luting agent system for enhanced adhesion of resin-based composites, conservative ceramic inlays, and ceramic shell crowns. The major focus of this project will be to produce a bonding agent that is as technique insensitive as possible. In addition, the bonding agent must also be compatible with the experimental composites currently under development and clinical evaluation at the University of Florida through NIH/NIDR Grant No. DE09292. The bonding ability will be based on resin infiltration of the bonding agent into a demineralized collagen film on the conditioned dentinal surface. To meet this objective, the following aims are proposed: 1) Test the hypothesis that amino acids, such as glycine and proline, can be used efficiently as conditioners for dentin, even if the dentin is contaminated with saliva. Since both glycine and proline are the main components of collage, we will further determine whether certain treatment conditions with these two amino acids cause collagen degradation. 2) Identify the most promising conditioning and priming aspects of collagen regarding resin infiltration, and test the hypothesis that a primer consisting of KAl(SO4)2.12H2O and ammoniac is as efficient as presently used primers. 3) Test the hypothesis that a polyacrylic acid, to which terminal and/or pendant amino acid groups and methylmethacrylate groups have been attached, enhances the infiltration ability of a primer into collagen. 4) Test the hypothesis that residuals of conditioners, moisture and Ca- and P-ions, present in the collagen web after etching, significantly affect the polymerization degree of the resin within the collagen network. By maximizing polymerization, we believe that maximal bond strength wil be achieved. 5) Test the hypothesis that the large variations in bond strength values are mainly due to defects induced during the bonding procedure. 6) Test the hypothesis that in vitro marginal leakage, determined with a diffusion marker, is related to the collagen film and the resin infiltration depth into that film. 7) In an animal study, test the hypothesis that the best materials identified in the previous aims will not cause any significant pulp damage despite aggressive etching of dentin. 8) Assuming that the results of Aim 7 are favorable, conduct a one-year clinical evaluation of the most promising product. The objective of that study will be to test the hypothesis that it is possible to achieve an almost 100% success rate regarding both retention and pulpal response with the total-etch technique.

最近，人们一直在寻找修复牙科的理想材料 重点介绍了牙本质粘结剂的发展和分析 与有条件的牙本质结合，并具有水解性稳定性。 关于债券的结果相互矛盾，而且差异很大。 这些药剂对条件性牙本质的强度。总体目标 这项建议的目的是开发一种牙本质粘结剂？？粘固剂。 用于增强树脂基复合材料附着力的系统，保守 陶瓷镶嵌和陶瓷贝壳冠。这件事的主要焦点是 该项目将生产一种粘结剂，是作为技术 尽可能麻木不仁。此外，粘结剂还必须是 与目前正在开发的实验复合材料兼容 和佛罗里达大学通过NIH/NIDR进行的临床评估 批准号DE09292。 粘接能力将基于粘接的树脂浸润性 在经过处理的牙本质上形成一层脱矿胶原膜 浮出水面。为了实现这一目标，提出了以下目标：1) 验证这样的假设：氨基酸，如甘氨酸和Pro，可以 有效地用作牙本质的护发素，即使牙本质是 被唾液污染。因为甘氨酸和脯氨酸都是主要的 拼贴的成分，我们将进一步确定是否一定 这两种氨基酸的治疗条件会导致胶原 退化。2)确定最有希望的条件化和启动 胶原蛋白与树脂渗透有关的方面，并检验这一假设 由KAl(SO4)2.12H2O和氨水组成的底漆同样有效 作为目前使用的底漆。3)检验一种聚丙烯酸酯的假设 酸，其末端和/或侧链氨基酸基团和 甲基丙烯酸甲酯基团已被附着，增强了渗透性 底漆转化为胶原蛋白的能力。4)检验残差假设 护发素，水分和钙磷离子，存在于胶原网中 蚀刻后，显著影响聚合度 胶原蛋白网络中的树脂。通过最大化聚合，我们 相信将达到最大的粘合强度。5)测试 假设键强度值的较大变化主要是 由于键合过程中产生的缺陷。6)测试 假设体外边际渗漏，用扩散法确定 标记物，与胶原膜和树脂的渗透深度有关 拍成那部电影。7)在一项动物研究中，验证这样的假设：最好的 在之前的目标中确定的材料不会导致任何重大 尽管牙本质有侵袭性的蚀刻，牙髓仍受到损伤。8)假设 AIM 7结果良好，进行为期一年的临床评估 最有希望的产品。这项研究目标将是 测试这样一种假设，即有可能实现几乎100%的成功 全酸蚀的固位率和牙髓反应率 技术。