CONDITIONING AND BONDING AGENTS FOR RESIN BASED COMPOSITES

树脂基复合材料的调理剂和粘合剂

• 批准号: 6104788
• 负责人: KARL-JOHAN M SODERHOLM
• 金额: $ 17.66万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-29 至 2001-09-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6104788
• 关键词: biomaterial development /preparation; biomaterial interface interaction; composite resins; dental adhesive /sealant; dental bonding material; dentin; tooth filling

The search for the ideal material for restorative dentistry has recently focused on the development and analysis of dentin bonding agents that bond to conditioned dentin and that are hydrolytically stable. Conflicting and quite variable results have been reported on the bond strength of these agents to conditioned dentin. The overall objective of this proposal is to develop a dentinal bonding agent-luting agent system for enhanced adhesion of resin-based composites, conservative ceramic inlays, and ceramic shell crowns. The major focus of this project will be to produce a bonding agent that is as technique insensitive as possible. In addition, the bonding agent must also be compatible with the experimental composites currently under development and clinical evaluation at the University of Florida through NIH/NIDR Grant No. DE09292. The bonding ability will be based on resin infiltration of the bonding agent into a demineralized collagen film on the conditioned dentinal surface. To meet this objective, the following aims are proposed: 1) Test the hypothesis that amino acids, such as glycine and proline, can be used efficiently as conditioners for dentin, even if the dentin is contaminated with saliva. Since both glycine and proline are the main components of collage, we will further determine whether certain treatment conditions with these two amino acids cause collagen degradation. 2) Identify the most promising conditioning and priming aspects of collagen regarding resin infiltration, and test the hypothesis that a primer consisting of KAl(SO4)2.12H2O and ammoniac is as efficient as presently used primers. 3) Test the hypothesis that a polyacrylic acid, to which terminal and/or pendant amino acid groups and methylmethacrylate groups have been attached, enhances the infiltration ability of a primer into collagen. 4) Test the hypothesis that residuals of conditioners, moisture and Ca- and P-ions, present in the collagen web after etching, significantly affect the polymerization degree of the resin within the collagen network. By maximizing polymerization, we believe that maximal bond strength wil be achieved. 5) Test the hypothesis that the large variations in bond strength values are mainly due to defects induced during the bonding procedure. 6) Test the hypothesis that in vitro marginal leakage, determined with a diffusion marker, is related to the collagen film and the resin infiltration depth into that film. 7) In an animal study, test the hypothesis that the best materials identified in the previous aims will not cause any significant pulp damage despite aggressive etching of dentin. 8) Assuming that the results of Aim 7 are favorable, conduct a one-year clinical evaluation of the most promising product. The objective of that study will be to test the hypothesis that it is possible to achieve an almost 100% success rate regarding both retention and pulpal response with the total-etch technique.

寻找理想的材料修复牙科最近 专注于牙本质粘合剂的开发和分析， 结合到调理的牙本质上并且是水解稳定的。 在债券上已经报道了许多不同的结果 这些试剂对条件牙本质的强度。 总体目标 本课题的目的是研制一种牙本质粘接剂--粘接剂 增强树脂基复合材料粘附性的系统，保守的 陶瓷嵌体和陶瓷壳冠。 这其中的主要焦点 该项目将生产一种粘合剂， 尽可能的不敏感。 此外，粘合剂还必须 与目前正在开发的实验复合材料兼容 并通过NIH/NIDR在佛罗里达大学进行临床评价 批准号：DE 09292。 粘合能力将基于粘合的树脂渗透 将所述试剂引入到经调理的牙本质上的脱矿胶原膜中， 面 为了实现这一目标，提出了以下目标：1） 检验氨基酸，如甘氨酸和脯氨酸， 可以有效地用作牙本质的调理剂，即使牙本质 被唾液污染了 由于甘氨酸和脯氨酸都是主要的 拼贴的组成部分，我们将进一步确定某些 这两种氨基酸的处理条件导致胶原蛋白 降解 2)确定最有希望的条件作用和启动 关于树脂浸润的胶原蛋白方面，并检验假设 由KAl（SO_4）_2·12H_2O和氨水组成的底漆同样有效， 如目前使用的底漆。 3)检验聚丙烯酸 酸，末端和/或侧基氨基酸基团和 甲基丙烯酸甲酯基团已经连接，增强了渗透 引物进入胶原蛋白的能力。 4)检验残差 胶原蛋白网中的调理剂、水分和钙离子和磷离子 蚀刻后，显着影响聚合度的 胶原网络中的树脂。 通过最大化聚合，我们 相信将获得最大的结合强度。 5)测试 假设粘结强度值的大变化主要是 这是由于在键合过程中引起的缺陷。 6)测试 假设用扩散测定体外边缘渗漏 标志物，与胶原膜和树脂浸润深度有关 放进电影里 7)在动物实验中，测试假设最好的 在先前的目标中确定的材料不会引起任何重大的 尽管侵蚀性牙本质，但牙髓损伤。 8)假设 目标7的结果是有利的，进行一年的临床评价 最有前途的产品。 这项研究的目的是 测试有可能实现几乎100%成功的假设 全酸蚀固位率和牙髓反应率 法