Impact of Wood Burning Air Pollution on Preeclampsia and other Pregnancy Outcomes in Temuco

特木科燃木空气污染对先兆子痫和其他妊娠结局的影响

• 批准号: NE/N000919/1
• 负责人: Roy Harrison
• 金额: $ 20.07万
• 依托单位: University of Birmingham
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=NE%2FN000919%2F1
• 关键词: Impact; Wood; Burning; Air; Pollution

Exposure to air pollutants has important acute and chronic health effects. An important effect that has been recently studied is pregnancy effects of pollutants. Scarce literature exists related to impacts of pollutants on preeclampsia and even less about the specific impact of residential wood burning emissions on pregnancy outcomes. Temuco is located in southern Chile and is known for its very high concentrations of air pollutants associated to residential wood burning. The main objective of this proposal is to determine whether exposure to air pollutants (specifically PM2.5 and wood burning tracer) have an impact on preeclampsia and other pregnancy outcomes (low birth weight, birth weight, small of gestational age, preterm birth). Reproductive data will be obtained from available databases at the Hospital Dr. Hernan Henriquez Aravena in Temuco and Padre LasCasas between 2009 and 2015. A total of approximately 18,000 pregnancies are expected. A year-long air pollution campaign will be performed in 3 10-week sessions, including a total of 20 fixed-site sampling points and mobile measurements. The studied pollutants will be PM2.5 and wood burning tracers within it (levoglucosan and others). Data will be fitted to produce spatial models and maps using the Land-Use Regression approach. This model will be used to estimate individual exposures by trimester to the subjects using residential geocoding and historical PM measurements. Finally, logistic and linear regression models will be fitted to estimate the impact of air pollutants exposure on the selected outcomes, adjusting for other individual and temporal variables. Expected results are i) an air pollution characterization of the campaigns with emphasis in wood burning tracers, ii) a Land-Use Regression model for air pollutants in Temuco including maps of air pollutants, iii) a pregnancy outcome descriptive characterization for the study period in Temuco, iv) results of the epidemiological study showing whether air pollutants (emphasizing wood burningemissions) have impacts on the studied pregnancy outcomes. To achieve these objective, we will assemble a capable team of both Chilean and UK researchers. Four ISI articles are expected as scientific production. Additionally, four master thesis, one doctoral thesis, and a two final workshops in Chile to disseminate the research findings.

接触空气污染物对健康有严重的急性和慢性影响。最近研究的一个重要影响是污染物对怀孕的影响。关于污染物对先兆子痫的影响的文献很少，关于住宅木材燃烧排放对妊娠结局的具体影响的文献更少。特木科位于智利南部，以其与住宅木材燃烧相关的高浓度空气污染物而闻名。该提案的主要目的是确定暴露于空气污染物（特别是PM2.5和木材燃烧示踪剂）是否对先兆子痫和其他妊娠结局（低出生体重，出生体重，胎龄小，早产）产生影响。将从特木科和Padre LasCasas的Hernan Henriquez Aravena医生医院的可用数据库中获得2009年至2015年的生殖数据。预计总共约有18 000名孕妇。为期一年的空气污染监测活动将分三个10周的时段进行，包括20个固定采样点和移动的测量。研究的污染物将是PM2.5和其中的木材燃烧示踪剂（左旋葡聚糖等）。将使用土地使用回归方法对数据进行拟合，以制作空间模型和地图。该模型将用于使用住宅地理编码和历史PM测量值估计受试者每三个月的个体暴露量。最后，将拟合逻辑和线性回归模型来估计空气污染物暴露对选定结果的影响，并针对其他个体和时间变量进行调整。预期结果是：i）活动的空气污染特征，重点是木材燃烧示踪剂，ii）特木科空气污染物的土地使用回归模型，包括空气污染物地图，iii）特木科研究期间的妊娠结局描述性特征，iv）流行病学研究结果，显示空气污染物（重点是木材燃烧排放）是否对研究的妊娠结局产生影响。为了实现这些目标，我们将组建一支由智利和英国研究人员组成的精干团队。预计将有四篇ISI文章作为科学成果。此外，四个硕士论文，一个博士论文，并在智利最后两个讲习班，以传播研究成果。

项目成果

Effect of residential wood-burning air pollution on pre-eclampsia in Temuco, Chile: a retrospective cohort study

智利特木科住宅燃木空气污染对先兆子痫的影响：一项回顾性队列研究

• 发表时间: 2019
• 作者: Quinteros Caceres M

Adverse pregnancy and perinatal outcomes in Latin America and the Caribbean: systematic review and meta-analysis.

• DOI: 10.26633/rpsp.2022.21
• 发表时间: 2022
• 期刊: Revista panamericana de salud publica = Pan American journal of public health
• 作者: Blanco E;Marin M;Nuñez L;Retamal E;Ossa X;Woolley KE;Oludotun T;Bartington SE;Delgado-Saborit JM;Harrison RM;Ruiz-Rudolph P;Quinteros ME
• 通讯作者: Quinteros ME

Perinatal health impacts of air pollution mitigation policies: applying g formula to preterm birth in Temuco/Padre Las Casas, Chile

空气污染缓解政策对围产期健康的影响：在智利 Temuco/Padre Las Casas 地区应用 g 配方治疗早产

• 发表时间: 2021
• 作者: Blanco E

Impactos en la salud perinatal de las políticas de mitigación de la contaminación del aire

空气污染缓解政治措施对围产期健康的影响

• 发表时间: 2021
• 作者: Blanco E

Exposure to ambient fine particulate matter and preterm birth: evidence from Temuco, Chile, a city heavily impacted by residential wood-burning

暴露于环境细颗粒物和早产：来自智利特木科的证据，这座城市受到住宅燃烧木材的严重影响

• 发表时间: 2020
• 作者: Blanco E