IN VIVO BIOMARKERS FOR REPRODUCTIVE TOXICITY IN NON-HUMAN PRIMATES
非人类灵长类动物生殖毒性的体内生物标志物
基本信息
- 批准号:6106367
- 负责人:
- 金额:$ 13.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1997
- 资助国家:美国
- 起止时间:1997-08-01 至 1999-07-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The goals of this project are: (1) to apply the biomarkers which have
been developed for human reproductive epidemiology in experiments with
a non-human primate model; (2) to carry out experiments in vivo which are
relevant to the mechanisms of toxicity to primate reproductive
physiology; (3) to test the utility of the in vivo biomarkers for
detecting and characterizing reproductive toxicity of TCDD, an
environmental chemical which has been shown to cause early fetal loss
(EFL) in macaques; and (4) to initiate pilot studies on the reproductive
toxicity of 13-cis retinoic acid, a vitamin A analogue, which is a potent
human teratogen that also causes increased EFL. In vivo biomarkers will
be validated for the animal model through surgical and chemical
interventions which mimic ovarian and fetal toxicity. Animals will be
treated with TCDD during the early post-implantation period and the
biomarkers which characterize the resulting reproductive toxicity will
be measured. This will include established ultrasonographic techniques
for monitoring early development and distinguishing between the various
forms of fetal loss after exposure to toxic agents, and endocrine
parameters (progesterone, 17beta-estradiol, chorionic gonadotropin,
relaxin) which will be assessed simultaneously. Collectively, the
results of these experiments will permit a comparison between the
physiologic events of early pregnancy in humans and nonhuman primates and
will address the following questions: (1) whether spontaneous early
fetal losses in humans are a model for toxicant-induced pregnancy
failures; (2) whether biomarkers for human surveillance are valid for
toxicant-induced events in the nonhuman primate; (3) whether the
mechanism of action of suspected reproductive toxicants can be evaluated
in whole animal experiments using the macaque model.
本项目的目标是:(1)应用生物标志物
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANDREW G HENDRICKX其他文献
ANDREW G HENDRICKX的其他文献
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{{ truncateString('ANDREW G HENDRICKX', 18)}}的其他基金
ENDOCRINE BIOMARKERS OF EARLY FETAL LOSS IN MACAQUES FOLLOWING EXPOSURE TO TCDD
接触 TCDD 后猕猴早期流产的内分泌生物标志物
- 批准号:
6116648 - 财政年份:1999
- 资助金额:
$ 13.03万 - 项目类别:
PATHOGENESIS OF RETINOIC ACID INDUCED EAR MALFORMATIONS IN PRIMATE MODEL
视黄酸诱发灵长类动物模型耳畸形的发病机制
- 批准号:
6116649 - 财政年份:1999
- 资助金额:
$ 13.03万 - 项目类别:
ENDOCRINE BIOMARKERS OF EARLY FETAL LOSS IN MACAQUES FOLLOWING EXPOSURE TO TCDD
接触 TCDD 后猕猴早期流产的内分泌生物标志物
- 批准号:
6277888 - 财政年份:1998
- 资助金额:
$ 13.03万 - 项目类别:
RETINOIC ACID INDUCES ABNORMAL HINDBRAIN & CRANIOFACIAL DEVELOPMENT IN MACAQUE
视黄酸导致后脑异常
- 批准号:
6277889 - 财政年份:1998
- 资助金额:
$ 13.03万 - 项目类别:
DEVELOPMENTAL TOXICITY OF EXCESSIVE VITAMIN INTAKE IN MACAQUE
猕猴摄入过多维生素的发育毒性
- 批准号:
6277887 - 财政年份:1998
- 资助金额:
$ 13.03万 - 项目类别:
DEVELOPMENTAL TOXICITY ASSESSMENT OF VITAMIN IN CYNOMOLGUS MONKEY
食蟹猴维生素的发育毒性评估
- 批准号:
6247758 - 财政年份:1997
- 资助金额:
$ 13.03万 - 项目类别:
BIOMARKERS OF EARLY FETAL LOSS IN MACAQUES TCDD: ENVIRONMENTAL TOXICITY MODEL
猕猴早期流产的生物标志物 TCDD:环境毒性模型
- 批准号:
6247757 - 财政年份:1997
- 资助金额:
$ 13.03万 - 项目类别:
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