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MOLECULAR MECHANISM OF CONTRACTION IN SMOOTH MUSCLE

MOLECULAR MECHANISM OF CONTRACTION IN SMOOTH MUSCLE
平滑肌收缩的分子机制
批准号：
6110120
负责人：
ROGER W CRAIG
金额：
$0.0万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-05-01 至 1999-04-30
来源：
https://reporter.nih.gov/project-details/6110120
关键词：
actins chemical structure conformation electron microscopy freeze etching guinea pigs image processing laboratory rabbit laboratory rat membrane channels muscle contraction myosin light chain kinase myosins phosphorylation polymerization protein kinase smooth muscle

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中文摘要
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英文摘要
The overall objective of this project is to obtain a detailed understanding of the molecular structure of the action and myosin filaments of relaxed vertebrate smooth muscle, and their arrangement in the contractile apparatus. Using these structures as a starting point, we also wish to determine how changes in the arrangement of the molecules or filaments are related to contraction of smooth muscle. The results should provide fundamental insights into the molecular mechanism of smooth muscle contraction and its regulation, and provide a basis for understanding structural defects that may occur in diseased states.
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会议论文
Mechanism of regulation of cardiac contraction by phosphorylation of myosin binding protein C
  • 批准号：
    10223413
  • 项目类别：
  • 资助金额：
    $68.04万
  • 财政年份：
    2018
  • 负责人：
    ROGER W CRAIG
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
Structure of The Interacting-Heads Motif in Myosin Filaments and Molecules
Structure of The Interacting-Heads Motif in Myosin Filaments and Molecules
Skeletal myosin-binding protein C (MyBP-C): molecular structure and function
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