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CORE--CAGED COMPOUND FACILITY

CORE--CAGED COMPOUND FACILITY
核心——笼式复合设施
批准号：
6242162
负责人：
JEFFREY W WALKER
金额：
$15.96万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-01-01 至 1997-12-31
来源：
https://reporter.nih.gov/project-details/6242162
关键词：
atomic absorption spectrometry biomedical facility chelating agents chemical synthesis diacylglycerols inositol mass spectrometry nuclear magnetic resonance spectroscopy optics photochemistry physical separation

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中文摘要
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英文摘要
The purpose of the this core facility is to provide photo-cleavable 'caged' compounds for use in subprojects within the Program. Compounds with known properties including caged chelators, caged pH probes, caged diacylglycerols and caged inositol phosphates will be made available in highly purified form. Several novel caged peptides, caged diacylglycerols and caged pH probes will be synthesized and characterized by chemical analysis, photolysis, and biochemical assays (enzyme or binding assays). In addition, chemical strategies will be explored for making certain compounds reversibly membrane permeant. The core will provide expertise in chemical synthesis, solid phase peptide synthesis, chemical analysis by nuclear magnetic resonance spectroscopy, UV/Vis absorption spectroscopy, mass spectroscopy, photochemistry and optics. Technical expertise in the use of caged compounds will also be provided including chromatographic analysis of purity, analysis of extents of photoconversion on photolysis, and optimization of photolysis optics for each experimental arrangement.
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REGULATION OF CARDIAC CONTRACTILITY BY DIACYLGLYCEROL
  • 批准号：
    6643674
  • 项目类别：
  • 资助金额：
    $19.96万
  • 财政年份：
    2002
  • 负责人：
    JEFFREY W WALKER
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
CORE--LIPID/PEPTIDE PROBE FACILITY
  • 批准号：
    6600929
  • 项目类别：
  • 资助金额：
    $19.96万
  • 财政年份：
    2002
  • 负责人：
    JEFFREY W WALKER
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
REGULATION OF CARDIAC CONTRACTILITY BY DIACYLGLYCEROL
  • 批准号：
    6600928
  • 项目类别：
  • 资助金额：
    $19.96万
  • 财政年份：
    2002
  • 负责人：
    JEFFREY W WALKER
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
CORE--LIPID/PEPTIDE PROBE FACILITY
  • 批准号：
    6643675
  • 项目类别：
  • 资助金额：
    $19.96万
  • 财政年份：
    2002
  • 负责人：
    JEFFREY W WALKER
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
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