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CORE--LIPID/PEPTIDE PROBE FACILITY

CORE--LIPID/PEPTIDE PROBE FACILITY
核心--脂质/肽探针设施
批准号：
6318387
负责人：
JEFFREY W WALKER
金额：
$19.96万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
项目状态：
已结题
起止时间：
2000-06-10 至 2001-05-31
来源：
https://reporter.nih.gov/project-details/6318387
关键词：
analytical chemistry biomedical facility clathrate diacylglycerols fatty acids fluorescent dye /probe high performance liquid chromatography mass spectrometry nuclear magnetic resonance spectroscopy peptide chemical synthesis protein purification radiotracer

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中文摘要
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英文摘要
Purpose This core will provide chemical synthesis services and expertise in probe development for subprojects within the Program. The majority of the service component will be developed to synthesis, purification, and analysis of peptides and caged compounds. Technical assistance in the use of commercial caged compounds will be provided including chromatographic analysis of compound purity, and determination of extent of photo-conversion under specific experimental conditions. Many of the compounds being used in the subprojects are not commercially available and mus be prepared on a regular basis. In some instances, compounds need to be radiolabeled, or have biotin or fluorophores attached for addressing specific issues regarding a compounds stability, localization, or effective concentration in cells. Labeling and the flexibility to otherwise customize reagents for specific purposes represent two of many significant advantages of having 'in house' chemical synthesis capabilities. Core staff in consultation with subproject personnel will design and implement synthetic strategies based upon the requirements of the physiological or biochemical system under investigation.
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REGULATION OF CARDIAC CONTRACTILITY BY DIACYLGLYCEROL
  • 批准号：
    6643674
  • 项目类别：
  • 资助金额：
    $19.96万
  • 财政年份：
    2002
  • 负责人：
    JEFFREY W WALKER
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
CORE--LIPID/PEPTIDE PROBE FACILITY
  • 批准号：
    6600929
  • 项目类别：
  • 资助金额：
    $19.96万
  • 财政年份：
    2002
  • 负责人：
    JEFFREY W WALKER
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
REGULATION OF CARDIAC CONTRACTILITY BY DIACYLGLYCEROL
  • 批准号：
    6600928
  • 项目类别：
  • 资助金额：
    $19.96万
  • 财政年份：
    2002
  • 负责人：
    JEFFREY W WALKER
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
CORE--LIPID/PEPTIDE PROBE FACILITY
  • 批准号：
    6643675
  • 项目类别：
  • 资助金额：
    $19.96万
  • 财政年份：
    2002
  • 负责人：
    JEFFREY W WALKER
  • 依托单位：
    UNIVERSITY OF WISCONSIN-MADISON
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