NATURAL CONTROL OF M AVIUM IN SAIDS

M AVIUM 对 SAIDS 的自然控制

• 批准号: 6247297
• 负责人: PETER J DIDIER
• 金额: $ 7.54万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-09 至 1998-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6247297
• 关键词: AIDS; Primates; animal tissue; bacteria; communicable diseases; immunology; lymphatic system; skin; technology /technique development; vaccines; virus

The incidence of M. avium infection (MAI) in the SAIDS colony has increased from undetectable levels in 1988 to 18-25% in recent years. This opportunistic infection produces diarrhea, cachexia, and sometimes pneumonia in severely immunocompromized monkeys with remarkable similarity to MAI in children with AIDS. We detect M. avium by culture and PCR and characterize isolates from the environment (soil and water) and monkeys by molecular fingerprint analysis. To date, isolates from the environment rarely infect deep tissues of monkeys. In vitro testing of monkey macrophages demonstrates that cells co-infected with SIV and a common strain of pathogenic M. avium found in our monkey colony produces higher than expected levels of virus. Protein components of our pathogenic strain are being characterized.

在SAIDs群体中，禽类分枝杆菌感染(MAI)的发病率为 从1988年检测不到的水平上升到最近几年的18-25%。 这种机会性感染会导致腹泻、恶病质和 有时免疫功能严重受损的猴子会出现肺炎 与艾滋病儿童的MAI有显著的相似性。我们检测到M。 Avium通过培养和聚合酶链式反应(PCR)鉴定 环境(土壤和水)和猴子的分子指纹图谱 分析。到目前为止，从环境中分离出来的菌株很少会深度感染 猴子的组织。猴巨噬细胞的体外检测 表明混合感染SIV和一种常见的SIV菌株的细胞 在我们的猴群中发现的致病性禽类分支杆菌产量高于 预期的病毒水平。我们致病菌株的蛋白质组分 正在被描述为。