CLINICAL PATHOPHYSIOLOGY OF ACUTE BRAIN INJURY

急性脑损伤的临床病理生理学

• 批准号: 2379824
• 负责人: WILLIAM J POWERS
• 金额: $ 73.14万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2379824
• 关键词: brain injury; cerebral hemorrhage; cerebral ischemia /hypoxia; pathologic process

The overall goal of this Program project is to investigate ischemia as a secondary mechanism of tissue damage in the early period following acute brain injury. Secondary mechanisms, occurring in a delayed manner, provide the best opportunity for successful therapeutic intervention. A better understanding of the pathophysiology of secondary tissue damage following acute brain injury is important if improvements are to be made in current therapy. We will investigate two types of acute brain injury head trauma and intracerebral hemorrhage. In project 1, Drs. Michael Diringer and Robert Grubb will use positron emission tomography (PET) to investigate the occurrence and duration of focal cerebral ischemia in acute traumatic brain injury in project 2, Drs. Michael Diringer and Robert Grubb will use PET to determine the effect of hyperventilation on regional cerebral blood flow and brain oxygenation in acute traumatic brain injury. In project 3, Drs. William Powers and Michael Diringer will use PET to investigate the occurrence and duration of focal cerebral ischemia in acute intracerebral hemorrhage. In project 4, Drs. William Powers and Michael Deringer will use PET to determine th effect of pharmacologic reduction of systemic arterial pressure on regional cerebral blood flow and brain oxygenation in acute intracerebral hemorrhage. The PET Facilities Core directed by Dr Powers will coordinate those aspects of the initial acquisition, reconstruction and archiving of the PET, clinical and CT data. The PET Image Analysis Core directed by Dr. Tom Videen will implement and validate improved methods for analysis of PET images. This Program Project draws on a combination of facilities and expertise at Washington University that is unique. It combines state-of-the-artPET equipment for quantitative neuroimaging located in an intensive car unity, expertise in the care of critically ill neurological patients and many years experience in studying cerebral blood flow and metabolism. This research will provide fundamentally important pathophysiologic information about the role of ischemia in producing secondary tissue damage in patients with acute brain injury due to head trauma and intracerebral hemorrhage. This information is will provide new understanding of the pathophysiology of these conditions which will be important in guiding future research toward the most fruitful approaches for ameliorating the devastating impact of acute brain injury. The results of these studies will have immediate and direct applicability to the thousands of patients each year who suffer from these diseases.

本计划项目的总体目标是研究缺血作为一种 急性心肌梗死后早期组织损伤的继发机制 脑损伤 次要机制，以延迟的方式发生， 为成功的治疗干预提供最佳机会。 一 更好地理解继发性组织损伤的病理生理学 如果要改善急性脑损伤， 在当前的治疗中。 我们将研究两种类型的急性脑损伤 头部外伤和脑出血 在一号项目中，迈克尔博士 迪林格和罗伯特·格拉布将使用正电子发射断层扫描（PET）， 研究脑缺血的发生和持续时间， 项目2中的急性创伤性脑损伤，Michael Diringer博士和 Robert Grubb将使用PET来确定过度换气对 急性创伤后局部脑血流和脑氧合的变化 脑损伤 在项目3中，威廉·鲍尔斯博士和迈克尔·迪林格博士将 用PET研究局灶性脑梗死的发生和持续时间 急性脑出血局部缺血 在4号项目中，威廉博士 Powers和Michael Deringer将使用PET来确定 药物降低局部脑动脉压 脑出血急性期血流量和脑氧合的变化 的 由鲍尔斯博士指导的PET设施核心将协调以下方面： PET的初始采集、重建和存档，临床 CT数据。 由Tom Videen博士指导的PET图像分析核心将 实施和验证用于PET图像分析的改进方法。 这 计划项目利用设施和专业知识的组合， 华盛顿大学是独一无二的。它结合了最先进的PET 用于定量神经成像的设备位于密集车单元中， 在重症神经病患者的护理专业知识和许多 年研究脑血流和代谢的经验。 这 研究将提供重要的病理生理信息 关于缺血在产生继发性组织损伤中的作用， 由于头部外伤和脑内出血引起的急性脑损伤患者 出血 这些信息将提供新的理解 这些条件的病理生理学将是重要的指导 未来的研究朝着最富有成效的方法，以改善 急性脑损伤的毁灭性影响。 这些研究的结果 将立即和直接适用于成千上万的病人， 每年有多少人患上这些疾病。