SYMPATHETIC FUNCTION IN ELDERLY HUMAN HYPERTENSION

这项提案的总体目标是确定 交感神经系统(SNS)功能的哪些与年龄相关的变化， 对胰岛素代谢影响的敏感性，以及对盐的敏感性 血压升高导致了老年人的高血压。我们 假设通常允许的补偿机制 老年人对这些与年龄相关的变化的适应能力受到损害 高血压。我们进一步假设一种改进的胰岛素 有氧运动六个月后的敏感性和血压下降 运动训练计划将与盐分的变化有关 敏感性、SNS功能和肾脏血流动力学(特别是 减少对钠的过滤)。

The overall objective of this proposal is to determine the extent to which age-related changes in sympathetic nervous system (SNS) function, sensitivity to the metabolic effects of insulin, and salt-sensitivity of blood pressure contribute to hypertension in the elderly. We hypothesize that the compensatory mechanisms which normally allow adaptation to these age-related changes are impaired in older hypertensives. We further hypothesize that an improvement insulin sensitivity and decrease in blood pressure following a six month aerobic exercise training program will be associated with alterations in salt sensitivity, SNS function and renal hemodynamics (specifically a decrease in filtration for sodium).