GROWTH RETARDATION--HPA AXIS RESPONSE TO CRH AND CORTISOL CHALLENGES

生长迟缓——HPA 轴对 CRH 和皮质醇挑战的反应

• 批准号: 6244565
• 负责人: Delia M Vazquez
• 金额: $ 2.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244565
• 关键词: behavioral /social science research tag; child (0-11); clinical research; corticotropin releasing factor; cortisol; hormone regulation /control mechanism; human subject; hypothalamic pituitary axis; pituitary adrenal axis; pituitary dwarfism; postnatal growth disorder; psychological stressor; somatotropin; stress

This proposal studies the growth hormone (GH) and hypothalamic pituitary adrenal (HPA) axis physiology in children with short stature and psychosocial dwarfs. The aim is to address the possibility that: repeated psychological stress during development activates the HPA axis; leads to an abnormal regulation of its elements and this ultimately is conducive to a tonic inhibition on GH release and growth failure.

本建议研究生长激素（GH）和下丘脑垂体 肾上腺（HPA）轴生理学在身材矮小的儿童和 心理社会侏儒 目的是解决以下可能性： 发育过程中反复的心理压力激活HPA轴; 导致其元素的异常调节，最终 有助于对GH释放和生长失败的滋补抑制。