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REGULATION OF EICOSANOID METABOLISM IN HUMAN MONOCYTES AND ALVEOLAR MACROPHAGE

REGULATION OF EICOSANOID METABOLISM IN HUMAN MONOCYTES AND ALVEOLAR MACROPHAGE
人单核细胞和肺泡巨噬细胞中二十烷酸代谢的调节
批准号：
6244578
负责人：
MICHAEL J. COFFEY
金额：
$2.22万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-02-20 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6244578
关键词：
HIV infections alveolar macrophages clinical research diagnostic respiratory lavage eicosanoid metabolism helper T lymphocyte human subject leukocyte count lipoxygenase monocyte prostaglandin endoperoxide synthase

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英文摘要
This study proposes to examine the mechanisms by which HIV increases cyclooxygenase (COX) and decreases 5-lipoxygenase (5-LO) metabolism in 1) monocytes (PBM) 2) alveolar macrophages (AM). The specific aims are to: 1) compare COX and 5-LO metabolism and expression of COX, and 5-LO enzymes in autologous AM and PBM from healthy HIV+ subjects as compared to normal subjects. This will be examined in 2 groups of varying severity as evidenced by the CD4+ T lymphocyte cell count; 2) determine the level of eicosanoids in bronchoalveolar lavage fluid from the HIV+.
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