REGULATION OF EICOSANOID METABOLISM IN HUMAN MONOCYTES AND ALVEOLAR MACROPHAGE

人单核细胞和肺泡巨噬细胞中二十烷酸代谢的调节

• 批准号: 6244578
• 负责人: MICHAEL J. COFFEY
• 金额: $ 2.22万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-20 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6244578
• 关键词: HIV infections; alveolar macrophages; clinical research; diagnostic respiratory lavage; eicosanoid metabolism; helper T lymphocyte; human subject; leukocyte count; lipoxygenase; monocyte; prostaglandin endoperoxide synthase

This study proposes to examine the mechanisms by which HIV increases cyclooxygenase (COX) and decreases 5-lipoxygenase (5-LO) metabolism in 1) monocytes (PBM) 2) alveolar macrophages (AM). The specific aims are to: 1) compare COX and 5-LO metabolism and expression of COX, and 5-LO enzymes in autologous AM and PBM from healthy HIV+ subjects as compared to normal subjects. This will be examined in 2 groups of varying severity as evidenced by the CD4+ T lymphocyte cell count; 2) determine the level of eicosanoids in bronchoalveolar lavage fluid from the HIV+.

这项研究旨在研究艾滋病毒增加的机制