EMISSION COMPUTED TOMOGRAPHY OF LOCAL CERBRAL FUNCTION

局部大脑功能的发射计算机断层扫描

• 批准号: 2478547
• 金额: $ 2.21万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/2478547
• 关键词: Alzheimer's disease; Parkinson's disease; brain metabolism; clinical research; glucose metabolism; human subject; positron emission tomography

The goal of this project is to identify and to examine longitudinally, with positron emission tomography, the earliest alterations in cerebral physiology associated with the onsets of Alzheimer's disease and of parkinsonian dementia. PET determined measures of cerebral glucose metabolism, blood flow, muscarinic cholinergic receptor densities, and presynaptic cholinergic markers will be determined in cross-sectional and longitudinal studies of controls and patients with dementing diseases.

这个项目的目标是确定和纵向检查， 用正电子发射断层扫描， 与阿尔茨海默病和阿尔茨海默病发作相关的生理学 帕金森痴呆症PET测定脑葡萄糖的测量 代谢、血流量、毒蕈碱胆碱能受体密度，以及 突触前胆碱能标记物将在横截面和 对照组和痴呆症患者的纵向研究。