PILOT TRIAL TO ASSESS IMMUNE STATUS IN CHILDREN WITH CHRONIC HEPATITIS B

评估慢性乙型肝炎儿童免疫状态的试点试验

• 批准号: 6245534
• 负责人: Richard J Grand
• 金额: $ 2.82万
• 依托单位: TUFTS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-01 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245534
• 关键词: aminoacid biosynthesis; arginine; chronic disease /disorder; clinical research; clinical trial phase I; hepatitis B; hepatitis B antigens; human subject; human therapy evaluation; interferon alpha; interleukin 1; interleukin 8; liver disorder chemotherapy; microorganism disease chemotherapy; microorganism immunology; nitric oxide; nitric oxide synthase; tumor necrosis factor alpha

Children with chronic hepatitis B infection are enrolled in this pilot study in an attempt to better understand the underlying cellular mechanisms responsible for clearance of the hepatitis B virus in children with chronic hepatitis B infection. Some of the children will undergo therapy with alpha-2b interferon for 4-6 months. Evaluation of in-vivo production of proinflammatory cytokines including interleukin one- beta, tumor necrosis factor-bp, and interleukin eight will be assayed prospectively as will the stable end-products of the L-arginine/nitric oxide biosynthetic pathway. In addition, serum antibodies to HBeAg and HBsAg will be assayed with a more sensitive experimental immunoassay.

慢性B型肝炎感染儿童纳入本次试点 研究试图更好地了解潜在的细胞 B肝炎病毒的清除机制 儿童慢性B型肝炎感染。 有些孩子会 用α-2b干扰素治疗4-6个月。 评价 体内产生促炎细胞因子，包括白细胞介素一， β，肿瘤坏死因子-bp和白细胞介素8将被测定 前瞻性地，L-精氨酸/硝酸盐的稳定终产物 氧化物生物合成途径 此外，血清HBeAg抗体和 将采用更灵敏的实验性免疫测定法测定HBsAg。