INTRANASAL CALCITONIN IN THE TREATMENT OF OSTEOPENIA AND OSTEOPOROSIS

鼻内降钙素治疗骨质减少和骨质疏松症

• 批准号: 7607247
• 负责人: Richard J Grand
• 金额: $ 0.94万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607247
• 关键词: Age; Bone Density; Calcitonin; Calcium; Computer Retrieval of Information on Scientific Projects Database; Diagnosis; End Point; Funding; Grant; Institution; Measures; Minerals; Osteoporosis; Outcome; Patients; Placebos; Research; Research Personnel; Resources; Source; Standards of Weights and Measures; Supplementation; United States National Institutes of Health; Vertebral column; Vitamin D; bone; sex; substantia spongiosa; treatment effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aim of the study is to compare the effect of treatment with nasally administered calcitonin plus calcium and vitamin D supplementation to that of treatment with placebo plus calcium and vitamin D supplementation on the lumbar bone mineral density of patients with the diagnosis of IBD and low lumbar bone mineral density (lumbar BMD 1 standard deviation or more below that of a healthy subject with the same age and sex). The primary endpoint will be lumbar BMD at 18 months after initiation of the treatment, measured by dual energy x-ray absorptiometry (DXA). We have selected lumbar spine BMD as the primary outcome variable because the lumbar spine is representative of trabecular bone. Trabecular bone has the most rapid turnover, and therefore reflects rapid changes in bone mineral mass most accurately and consistently.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该研究的具体目的是比较经鼻给予降钙素加钙和维生素 D 补充剂的治疗与安慰剂加钙和维生素 D 补充剂的治疗对 IBD 诊断和低腰椎骨矿物质密度（腰椎 BMD 比同年龄和性别的健康受试者低 1 个标准差或更多）患者的腰椎骨矿物质密度的影响。 主要终点是治疗开始后 18 个月时的腰椎 BMD，通过双能 X 射线吸收测定法 (DXA) 测量。我们选择腰椎 BMD 作为主要结果变量，因为腰椎是骨小梁的代表。 骨小梁的周转速度最快，因此能够最准确、一致地反映骨矿物质量的快速变化。