GENETICS OF GROWTH FAILURE IN PEDIATRIC INFLAMMATORY BOWEL DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 我们推测，儿童炎症性肠病（IBD）的“预模式”生长失败过程是由遗传因素决定的。 与生长和食欲调节、免疫反应和应激反应相互作用的基因以及矮小基因是IBD相关生长障碍的功能候选者。 我们的具体目标是探索与线性生长相关的表型特征与候选遗传位点变异的相关性，以阐明IBD儿童生长失败的遗传基础。 阐明IBD生长障碍的遗传基础可能会提供新的治疗方法，或有助于确定为什么对现有营养治疗或药物的反应是异质性的。 早期干预的方法也是可能的，更明智的遗传咨询可能最终可用于指导受影响的亲属在治疗决策。 这项研究是儿童医院炎症性肠病中心和麻省理工学院基因组研究中心的合作。 这项描述性研究也将作为计划中的IBD遗传学研究联盟研究的试点。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that the "pre-patterned" course of growth failure in pediatric inflammatory bowel disease (IBD) is determined by genetic factors. Genes interacting with growth and appetite regulation, immune responses, and stress responses, as well as the short-stature genes are functional candidates for IBD-related growth failure. Our specific aim is to explore the association of phenotypic characteristics related to linear growth with variations at candidate genetic loci, in order to elucidate the genetic basis for growth failure in children with IBD. Elucidating the genetic basis for growth failure in IBD might provide novel therapeutic approaches, or help define why response to available nutritional treatment or medication is heterogeneous. Early intervention approaches might also be possible, and more informed genetic counseling might ultimately be available to guide affected kindred in therapeutic decisions. This study is a collaboration of the Center for Inflammatory Bowel Disease at the Children's Hospital and the MIT Center for Genome Research. This descriptive study will also serve as a pilot for a planned IBD Genetics Research Consortium study.