INTRANASAL CALCITONIN IN THE TREATMENT OF OSTEOPENIA AND OSTEOPOROSIS IN CHILD

鼻内降钙素治疗儿童骨质减少和骨质疏松症

• 批准号: 7380724
• 负责人: Richard J Grand
• 金额: $ 8.2万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380724
• 关键词: INTRANASAL; CALCITONIN; TREATMENT; OSTEOPENIA; OSTEOPOROSIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific aim of the study is to compare the effect of treatment with nasally administered calcitonin plus calcium and vitamin D supplementation to that of treatment with placebo plus calcium and vitamin D supplementation on the lumbar bone mineral density of patients with the diagnosis of IBD and low lumbar bone mineral density (lumbar BMD 1 standard deviation or more below that of a healthy subject with the same age and sex). The primary endpoint will be lumbar BMD at 18 months after intiation of the treatment, measured by dual energy x-ray absorptiometry (DXA). We have selected lumbar spine BMD as the primary outcome variable because the lumbar spine is representative of trabecular bone. Trabecular bone has the most rapid turnover, and therefore reflects rapid changes in bone mineral mass most accurately and consistantly.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的具体目的是比较鼻给药降钙素加补钙和维生素D治疗与安慰剂加补钙和维生素D治疗对诊断为IBD和腰椎骨密度低的患者（腰椎骨密度低于相同年龄和性别的健康受试者的1个标准差或更多）腰椎骨密度的影响。主要终点将是治疗开始后18个月的腰椎骨密度，用双能x线骨密度仪（DXA）测量。我们选择腰椎骨密度作为主要结果变量，因为腰椎是小梁骨的代表。小梁骨的更新速度最快，因此最准确、最一致地反映了骨矿物质量的快速变化。