DIETARY CALCIUM & ARGININE IN DEVELOPMENT OF PREECLAMPSIA IN HISPANIC WOMEN

低钙尿症与先兆子痫有关？无论是饮食原因 钙摄入量减少或由于钙稳态的改变 目前尚不清楚怀孕的少女面临的风险增加， 以及目前妊娠诱发的 高血压或先兆子痫在西班牙裔青少年人群中， 目前为25%。因此，本研究的目的是确定 膳食钙或精氨酸摄入量减少与 先兆子痫的发病率 M01RR000510986 瘦素是一种由脂肪细胞分泌的激素， 下丘脑，抑制食物摄入，增加能量 支出这项研究的目的是检验假设， 大量营养素组成和膳食都将导致增加 血清瘦素10名健康受试者参加了这项研究，5名肥胖者 5瘦。 所有受试者的体重稳定且处于最大体重。 受试者被指示遵循以下体重维持饮食： 高碳水化合物或高脂肪5天。受试者 然后给予在30分钟内消耗的膳食。 这顿饭与受试者一直遵循的饮食相同， 前5天，热量含量为每日热量的40% 保持体重的要求。 在不同的地方抽血 在整个研究的时间点，并评估瘦素和其他 代谢参数 受试者出院， 4周后用替代饮食重复。 总的来说，瘦素 水平与BMR和体脂百分比高度相关。在 基线时，肥胖受试者的胰岛素、FFA、甘油三酯和瘦素水平较高 程度.急性进食导致胰岛素水平升高， 然而，游离脂肪酸中没有观察到瘦素的变化。双向 方差分析，大量营养素膳食组成没有影响 瘦素和胰岛素水平，以及180分钟时的甘油和FFA水平 餐后受饮食影响。相反，只有身体形态 影响胰岛素和瘦素水平。总之，无论是大量营养素 膳食组成和膳食对人血清瘦素的影响。 因此在 对于人类来说，瘦素可能在长期的能量平衡中发挥更大的作用。

Hypocalciuria associated with preeclampsia? Whether this is dietary due to decreased calcium intake or due to alterations in calcium homeostasis is unclear teenage women undergoing pregnancy are at an increased risk for ppreeclampsia and the current frequency of pregnancy-induced- hypertension or preeclampsia in our hispanic teenage population is currently 25%. Therefore, the purpose of this study is to determine if decreased dietary calcium or arginine intake are associated with preeclampsia in this population of women. M01RR000510986 Leptin is a hormone secreted by adipocytes which is thought to feed back to the hypothalamus and inhibit food intake as well as increase energy expenditure. The study was designed to test the hypothesis that macronutrient composition and a meal will both result in increases in serum leptin. Ten healthy subjects participated in this study, 5 obese and 5 lean. All subjects were weight stable and at maximum body weight. Subjects were instructed to follow a weight maintenance diet of either high carbohydrate or high fat for 5 days prior to the study. The subject was then given a meal which was consumed over 30 min. The composition of the meal was identical to the diet the subject had been following for the previous 5 days and the caloric content was 40% of daily caloric requirements for weight maintenance. Blood was drawn at various timepoints throughout the study and asssayed for leptin and other metabolic parametrs. The subjects were discharged and the process repeated with alternate diet after 4 weeks had passed. Overall, leptin levels were highly correlated with both BMR and percent body fat. At baseline, obese subjects had higher insulin, FFA, triglyceride and leptin levels. The acute meal resulted in increased insulin levels and decreased free fatty acids, however, no change in leptin was seen. By two way analysis of variance, macronutrient dietary composition did not affect leptin nor insulin levels, and only glycerol and FFA levels at 180 min post meal were affected by the diet. Conversely, only body habitus affected insulin and leptin levels. In conclusion, neither macronutrient dietary composition nor meal affect serum leptin in humans. Thus in humans, leptin may play a greater role in long term energy balance.