General Clinical Research Center

描述(由申请人提供)：目前的提案是由科罗拉多大学丹佛分校和健康科学中心(UCDHSC)以及国家犹太医学和研究中心(NJMRC)和科罗拉多大学博尔德分校(UCB)的两颗相关卫星进行为期三年的竞争性续签，以支持科罗拉多州的成人普通研究中心。UCDHSC成人GCRC已经进入不间断支持的第45个年头。该应用程序请求支持科罗拉多大学医院(UCH)的1,724天住院“A”天、NJMRC的3天“A”天、UCH的19,232次门诊“A”次、NJMRC的2,164次和UCB的6,953次。所描述的研究总共涉及245个方案(UCDHSC 117个，NJMRC 59个，UCB 69个)，代表来自UCDHSC医学院、护理和药剂学学院、NJMRC医学系和儿科以及UCB综合生理学、心理学和分子、细胞和发育生物学的研究人员。患者从整个落基山地区转诊到科罗拉多大学系统，从世界各地转诊到NJMRC。成人GCRC提供专门的护理服务，对研究对象进行复杂和仔细的监测，提供具有精确饮食和膳食评估的生物营养服务，核心实验室包括UCH的生物化学/免疫分析/分子生物学核心，NJMRC的炎症/免疫和心理社会评估中心，以及UCB的生理学核心，所有这些都提供最先进的诊断能力。此外，成人GCRC提供大量的培训机会，以及详细的统计和数据管理能力(信息学)。UCDHSC GCRC的成人GCRC服务的主要研究项目包括癌症、充血性心力衰竭、糖尿病、运动、丙型肝炎、艾滋病毒、代谢、营养和肥胖；在NJMRC的重点是哮喘、职业性和肉芽肿性肺部疾病、特应性疾病和疫苗开发；以及UCB衰老、运动和血管生物学。在所有三个地点，都是 科罗拉多州成人GCRC的组成部分致力于人类疾病的诊断和管理 疾病，以及将基础生物学转化为改进的健康评估和维护； 治疗学。

DESCRIPTION (provided by applicant): The current proposal is a three-year competitive renewal by the University of Colorado at Denver and Health Sciences Center (UCDHSC) and two related satellites at the National Jewish Medical and Research Center (NJMRC) and University of Colorado at Boulder (UCB) to support the Adult General Research Center in Colorado. The UCDHSC Adult GCRC has entered its 45th year of uninterrupted support. This application requests support for 1,724 inpatient "A" days at the University of Colorado Hospital (UCH), 3 "A" days at NJMRC, and 19,232 outpatient "A" visits at UCH, 2,164 at NJMRC and 6,953 at UCB. The research described involves a combined total of 245 protocols (117 at UCDHSC, 59 at NJMRC, 69 at UCB) representing investigators from the schools of Medicine, Nursing and Pharmacy at UCDHSC, the departments of Medicine and Pediatrics at NJMRC, and Integrative Physiology, Psychology, and Molecular, Cellular and Developmental Biology at UCB. Patients are referred to the University of Colorado system from the entire Rocky Mountain Region and to NJMRC from all over the world. The Adult GCRC provides specialized nursing care with sophisticated and careful monitoring of research subjects, bionutrition services with precision diets and dietary assessment, core laboratories including the Biochemistry/lmmunoassay/Molecular Biology Core at UCH, Inflammation/ Immunology and Psychosocial Assessment Cores at NJMRC, and Physiology Core at UCB, all of which provide state-of-the-art diagnostic capabilities. In addition, the Adult GCRC provides numerous opportunities for training, and detailed statistical and data management capabilities (informatics). The major research programs served by the Adult GCRC at UCDHSC GCRC include cancer, congestive heart failure, diabetes, exercise, hepatitis C, HIV, metabolism, nutrition and obesity; emphasized at NJMRC are asthma, occupational and granulomatous lung diseases, atopic disorders, and vaccine development; and at UCB aging, exercise, and vascular biology. At all three sites, all components of the Adult GCRC in Colorado are dedicated to the diagnosis and management of human diseases, and the translation of basic biology into improved health assessment and maintenance, and therapeutics.