General Clinical Research Center

描述（由申请人提供）：目前的提案是由丹佛科罗拉多大学和健康科学中心（UCDHSC）以及国家犹太医学和研究中心（NJMRC）和科罗拉多大学博尔德分校（UCB）的两个相关卫星进行为期三年的竞争性更新，以支持科罗拉多州成人一般研究中心。UCDHSC成人GCRC已经进入了第45个不间断支持的年头。此应用程序要求支持科罗拉多大学医院（UCH）的1,724个住院“A”日，NJMRC的3个“A”日，以及UCH的19,232次门诊“A”访问，NJMRC的2,164次和UCB的6,953次。所描述的研究共涉及245项协议（117项在UCDHSC， 59项在NJMRC， 69项在UCB），代表了来自UCDHSC医学院、护理学院和药学院、NJMRC医学和儿科部门以及UCB综合生理学、心理学、分子、细胞和发育生物学的研究人员。患者从整个落基山脉地区转到科罗拉多大学系统，从世界各地转到NJMRC。成人GCRC提供专业护理，对研究对象进行复杂和仔细的监测，提供精确饮食和饮食评估的生物营养服务，核心实验室包括UCH的生物化学/免疫测定/分子生物学核心，NJMRC的炎症/免疫学和社会心理评估核心以及UCB的生理学核心，所有这些都提供了最先进的诊断能力。此外，成人GCRC提供了许多培训机会，以及详细的统计和数据管理能力（信息学）。成人GCRC的主要研究项目包括癌症、充血性心力衰竭、糖尿病、运动、丙型肝炎、艾滋病毒、代谢、营养和肥胖；NJMRC强调哮喘、职业性和肉芽肿性肺部疾病、特应性疾病和疫苗开发；以及UCB的衰老、运动和血管生物学。三个地点都是

DESCRIPTION (provided by applicant): The current proposal is a three-year competitive renewal by the University of Colorado at Denver and Health Sciences Center (UCDHSC) and two related satellites at the National Jewish Medical and Research Center (NJMRC) and University of Colorado at Boulder (UCB) to support the Adult General Research Center in Colorado. The UCDHSC Adult GCRC has entered its 45th year of uninterrupted support. This application requests support for 1,724 inpatient "A" days at the University of Colorado Hospital (UCH), 3 "A" days at NJMRC, and 19,232 outpatient "A" visits at UCH, 2,164 at NJMRC and 6,953 at UCB. The research described involves a combined total of 245 protocols (117 at UCDHSC, 59 at NJMRC, 69 at UCB) representing investigators from the schools of Medicine, Nursing and Pharmacy at UCDHSC, the departments of Medicine and Pediatrics at NJMRC, and Integrative Physiology, Psychology, and Molecular, Cellular and Developmental Biology at UCB. Patients are referred to the University of Colorado system from the entire Rocky Mountain Region and to NJMRC from all over the world. The Adult GCRC provides specialized nursing care with sophisticated and careful monitoring of research subjects, bionutrition services with precision diets and dietary assessment, core laboratories including the Biochemistry/lmmunoassay/Molecular Biology Core at UCH, Inflammation/ Immunology and Psychosocial Assessment Cores at NJMRC, and Physiology Core at UCB, all of which provide state-of-the-art diagnostic capabilities. In addition, the Adult GCRC provides numerous opportunities for training, and detailed statistical and data management capabilities (informatics). The major research programs served by the Adult GCRC at UCDHSC GCRC include cancer, congestive heart failure, diabetes, exercise, hepatitis C, HIV, metabolism, nutrition and obesity; emphasized at NJMRC are asthma, occupational and granulomatous lung diseases, atopic disorders, and vaccine development; and at UCB aging, exercise, and vascular biology. At all three sites, all components of the Adult GCRC in Colorado are dedicated to the diagnosis and management of human diseases, and the translation of basic biology into improved health assessment and maintenance, and therapeutics.