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DRUG METABOLISM IN LUNG CANCER

DRUG METABOLISM IN LUNG CANCER
肺癌中的药物代谢
批准号：
6245615
负责人：
ROBERT A BRANCH
金额：
$1.76万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
项目状态：
已结题
起止时间：
1997-03-18 至 1997-11-30
来源：
https://reporter.nih.gov/project-details/6245615
关键词：
cancer risk clinical research drug metabolism enzyme activity gene mutation human genetic material tag human subject lung neoplasms messenger RNA natural gene amplification neoplasm /cancer genetics oncogenes phenotype

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中文摘要
翻译
这项肺癌病例对照研究的目的是 确定药物代谢活性的表型指标是否为 以匹兹堡药物鸡尾酒在全身或从 肺内单个药物代谢酶基因表达的定量研究 实质、支气管粘膜或肺肿瘤将与风险相关 罹患肺癌的风险。药物代谢活性的衡量标准将 也与特定的突变和癌基因扩增有关，如 以及肿瘤的生物学行为。
英文摘要
The objective of this case controlled study in lung cancer is to determine if phenotypic measures of drug metabolizing activity as measured by the Pittsburgh drug cocktail in the whole body or from quantitation of mRNA for individual drug metabolizing enzymes in lung parenchyma, bronchial mucosa or lung tumor will be related to the risk of developing lung cancer. Measures of drug metabolizing activity will also be related to specific mutations and oncogene amplification as well as the biological behavior of the tumor.
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会议论文
Community Appalachian Investigation and Research Network (CAIRN)
INFORMATION TECHNOLOGY AND BIOSTATISTICS CORE
VALIDATION OF MODIFIED PITTSBURGH COCKTAIL STUDY
WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJ
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