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DEVELOPMENT OF FLURBIPROFEN AS A SELECTIVE PROBE OF CYP2C9

DEVELOPMENT OF FLURBIPROFEN AS A SELECTIVE PROBE OF CYP2C9
氟比洛芬作为 CYP2C9 选择性探针的开发
批准号：
6304674
负责人：
ROBERT A BRANCH
金额：
$0.3万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
项目状态：
已结题
起止时间：
1999-12-01 至 2000-11-30
来源：
https://reporter.nih.gov/project-details/6304674
关键词：
analgesics clinical research cytochrome P450 drug metabolism human subject pathologic process prognosis

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中文摘要
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英文摘要
Drug metabolism is an important process in the body involved in drug elimination as well as in activation of some compounds and the consequential development of toxicities. This project is designed to investigate the potential use of Flubiprofen as a selective probe of CYP2C9 and the possibility of incorporating it into an already developed five drug cocktail. The objective is to be able to use it in large population studies to assess the role of CYP2C9 in the pathogenesis or prognosis of diseases.
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